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DUP-697

DUP-697 Structure
CAS No.
88149-94-4
Chemical Name:
DUP-697
Synonyms
BFMeT;DUP-697;DuP697,DuP 697;DuP-697 Assay Reagent;5-BROMO-2-(4-FLUOROPHENYL)-3-(4-(METHYLSULFONYL)PHENYL)THIOPHENE;Thiophene, 5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-
CBNumber:
CB8397180
Molecular Formula:
C17H12BrFO2S2
Molecular Weight:
411.31
MOL File:
88149-94-4.mol
Modify Date:
2024/7/2 8:55:32
Request For Quotation

DUP-697 Properties

storage temp. 2-8°C
solubility DMF: 54 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 7 mg/ml
form White to off-white solid.
color White to off-white

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36

DUP-697 Chemical Properties,Uses,Production

Description

DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1. The IC50 values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively. The IC50 for the inhibition of human recombinant COX-1 after the same time intervals is 9 μM. DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin.

Uses

DuP-697 is a thiophene that inhibits COX-2 and acts as a NSAID.

Biological Activity

Potent and selective inhibitor of cyclooxygenase-2 (IC 50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo . Orally active.

DUP-697 Preparation Products And Raw materials

Raw materials

Preparation Products

DUP-697 Suppliers

Global( 72)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Hebei Miaoyin Technology Co.,Ltd +86-17367732028 +86-17367732028 China 3581 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48465 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9268 58 Inquiry
Chunchuang (Wuhan) Technology Co., Ltd 15342225168 China 9999 58 Inquiry
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 China 3433 58 Inquiry
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 China 9977 58 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9806 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
Hebei Miaoyin Technology Co.,Ltd 58
Aladdin Scientific 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
RD International Technology Co., Limited 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Shanghai EFE Biological Technology Co., Ltd. 58

DUP-697 Spectrum

DUP-697(88149-94-4)1HNMR

88149-94-4(DUP-697)Related Search:

NS-398 Indometacin Piroxicam (S)-(+)-Ibuprofen Ibuprofen
Phenidone (R)-(-)-IBUPROFEN 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE Meloxicam Naproxen
MECLOFENAMATE SODIUM SC-560 Sulindac sulfide APHS N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE
2-(4-Fluorophenyl)-thiophene DUP-697 2-BROMO-5-PHENYLTHIOPHENE
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DUP-697 5-BROMO-2-(4-FLUOROPHENYL)-3-(4-(METHYLSULFONYL)PHENYL)THIOPHENE BFMeT DuP-697 Assay Reagent Thiophene, 5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]- DuP697,DuP 697 88149-94-4 C17H12BrFO2S2 Lipid signaling API intermediates