Chinese english Japanese Germany Korea

(R)-(-)-IBUPROFEN

(R)-(-)-IBUPROFEN Structure
CAS No.
51146-57-7
Chemical Name:
(R)-(-)-IBUPROFEN
Synonyms
(R)-IBUPROFEN;(R)-2-(4-Isobutylphenyl)propanoic acid;l-Ibuprofen;levibuprofen;(-)-Ibuprofen;(-)-Ibuprophen;2-Yl)carbamate;(R)-(-)-Ibupr en;(R)-(-)-IBUPROFEN;Ibuprofen (R)-Isomer
CBNumber:
CB3393273
Molecular Formula:
C13H18O2
Molecular Weight:
206.29
MOL File:
51146-57-7.mol
Modify Date:
2023/5/18 11:31:18
Request For Quotation

(R)-(-)-IBUPROFEN Properties

Melting point 41-42°C
Boiling point 305.14°C (rough estimate)
Density 1.0176 (rough estimate)
refractive index 1.5290 (estimate)
storage temp. Sealed in dry,2-8°C
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form White crystalline powder.
pka 4.41±0.10(Predicted)
color Colourless to Pale Beige Oil
Water Solubility 369.3mg/L(25 ºC)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  24/25
HS Code  29155090

(R)-(-)-IBUPROFEN Chemical Properties,Uses,Production

Description

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53 μM, respectively). It is commonly synthesized as a racemic mixture of (S) and (R) isomers (Item No. item 70280). (R)-Ibuprofen is an enantiomer that is generally not considered a COX inhibitor and is instead thought to be involved in pathways of lipid metabolism as it is incorporated into triglycerides along with fatty acids. The (R) enantiomer can, however, inhibit NF-κB activation (IC50 = 121.8 μM) in response to T-cell stimulation as well as block superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 40-100 μM). 50-60% of (R)-ibuprofen is inverted to (S)-ibuprofen in humans after oral administration.

Chemical Properties

White Crystalline Solid

Purification Methods

Crystallise the (+) and (-) acids from EtOH or aqueous EtOH. The racemate which crystallises from pet ether with m 75-77o is sparingly soluble in H2O and has IR (film) 1705 (C=O), 2300—3700 (OH broad)cm-1. It is used as a non-steroidal anti-inflammatory. [Shiori et al. J Org Chem 43 2936 1978, Kaiser et al. J Pharm Sci 65 269 1976, J Pharm Sci 81 221 1992, Freer Acta Cryst (C) 49 1378 1993 for the (S+)-enantiomer.]

(R)-(-)-IBUPROFEN Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-(-)-IBUPROFEN Suppliers

Global( 151)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Synthink Research Chemicals 09158051123 Pune, India 398 58 Inquiry
Clearsynth Labs 91-22-45045900 Maharashtra, India 3889 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21667 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29888 58 Inquiry
Supplier Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharma Affiliates 58
Synthink Research Chemicals 58
Clearsynth Labs 58
Henan Tianfu Chemical Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58

(R)-(-)-IBUPROFEN Spectrum

(R)-(-)-IBUPROFEN(51146-57-7)1HNMR

51146-57-7((R)-(-)-IBUPROFEN)Related Search:

IBUPROFEN IMPURITY D,IBUPROFEN IMP D IBUPROFEN IMPURITY J α-Methyl-4-(isobutyl)phenylacetic acid, Ibuprofen,Ibuprofen (FDA),R,S-Ibuprofen,rac Ibuprofen,IBUPROFEN,(+/-)-IBUPROFEN IBUPROFEN IMPURITY E,IBUPROFEN IMP E 1-Hydroxyibuprofen
(S)-(+)-Ibuprofen 2-[4-(2-Methylpropyl)phenyl] ethanol 6-isobutyl-3-methyl-2,3-dihydro-1H-inden-1-one 4-(2-Methylpropyl)benzeneethanol Ibuprofen EP Impurity I
3-(4-ISOBUTYL-PHENYL)-PROPIONIC ACID p-Isobutylstyrene rac a-Hydroxy Ibuprofen (2RS)-2-(4-N-PROPYLPHENYL)PROPANOIC ACID trans-Ibuprofen IMpurity G
IBUPROFEN IMPURITY C,IBUPROFEN IMP C IBUPROFEN IMP N IBUPROFEN IMP F2,Ibuprofen methyl
chevron_left

1of4

chevron_right
(R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID (R)-(-)-IBUPROFEN (-)-Ibuprophen Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (R)- Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αR)- l-Ibuprofen R-(-)-p-Isobutylhydratropic acid (aR)-a-Methyl-4-(2-methylpropyl)benzeneacetic Acid Benzeneacetic acid, a-Methyl-4-(2-Methylpropyl)-, (aR)- (alphaR)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid levibuprofen Ibuprofen Impurity 20((R)-Isomer) (R)-(-)-Ibupr en (R)-(-)-Ibuprofen ((R)-Ibuprofen) (R)-(-)-ibuprofen reference substance Ibuprofen (R)-Isomer (R)-(-)-IBUPROFEN USP/EP/BP (R)-IbuprofenQ: What is (R)-Ibuprofen Q: What is the CAS Number of (R)-Ibuprofen Q: What is the storage condition of (R)-Ibuprofen Q: What are the applications of (R)-Ibuprofen 5-Triiodo-L-thyronine sodium (R)-IBUPROFEN (R)-2-(4-Isobutylphenyl)propanoic acid (-)-Ibuprofen 2-Yl)carbamate (αR)?-α-?Methyl-?4-?(2-?methylpropyl)?-benzeneacetic Acid 51146-57-7 1146-57-7 Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Chiral Reagents