(S)-(+)-Ibuprofen

CAS No.: 51146-56-6

Chemical Name:: (S)-(+)-Ibuprofen

Synonyms: DEXIBUPROFEN;(S)-IBUPROFEN;(S)-2-(4-Isobutylphenyl)propanoic acid;Seractil;d-Ibuprofen;Ramelteon-7;exibuprofen;Deibuprofen;(+)-Ibuprofen;Dextrobuprofen

CBNumber:: CB0699655

Molecular Formula:: C13H18O2

Molecular Weight:: 206.28

MOL File:: 51146-56-6.mol

MSDS File:: SDS

Modify Date:: 2024/6/13 17:03:25

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(S)-(+)-Ibuprofen Properties

Melting point	49-53 °C(lit.)
alpha	57 º (c=2, EtOH)
Boiling point	285.14°C (rough estimate)
Density	1.0364 (rough estimate)
refractive index	59 ° (C=2, EtOH)
Flash point	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.5 mg/mL
pka	4.41±0.10(Predicted)
form	solid
color	white
optical activity	[α]20/D +59°, c = 2 in ethanol
Water Solubility	insoluble
BRN	3590022
Stability	Stable. Incompatible with strong oxidizing agents.
InChIKey	HEFNNWSXXWATRW-JTQLQIEISA-N
CAS DataBase Reference	51146-56-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Risk Statements

63-22

Safety Statements

45-36/37

WGK Germany

HS Code

29163990

NFPA 704

	0
2		0

(S)-(+)-Ibuprofen price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	375160	(S)-(+)-Ibuprofen ReagentPlus?, 99%	51146-56-6	1G	₹3788.75	2022-06-14	Buy
Sigma-Aldrich(India)	375160	(S)-(+)-Ibuprofen ReagentPlus?, 99%	51146-56-6	5G	₹11214.7	2022-06-14	Buy
TCI Chemicals (India)	I0549	(S)-(+)-Ibuprofen min. 98.0 %	51146-56-6	1G	₹3700	2022-05-26	Buy
TCI Chemicals (India)	I0549	(S)-(+)-Ibuprofen min. 98.0 %	51146-56-6	5G	₹10100	2022-05-26	Buy

Product number	Packaging	Price	Buy
375160	1G	₹3788.75	Buy
375160	5G	₹11214.7	Buy
I0549	1G	₹3700	Buy
I0549	5G	₹10100	Buy

(S)-(+)-Ibuprofen Chemical Properties,Uses,Production

Description

Dexibuprofen, the S-(+)-isomer of the widely used NSAID agent ibuprofen, was launched in Austria for the treatment of rheumatoid arthritis. While the racemic compound is commonly used clinically, the antiinflammatory activity is mediated via the S-isomer by inhibition of prostaglandin synthesis. It has also been demonstrated that the R-isomer is converted to the Santipode in vivo via a CoA thioester intermediate. Since CoA plays a pivotal role in intermediary metabolism and maintenance of the [acyl-CoA], generation of R-ibuprofen-CoA competitively inhibits many CoA-dependent reactions, which consequently produces perturbations of hepatocyte Intermediary metabolism and mitocondrial function. Pure S-ibuprofen usage, therefore, is preferred allowing a reduction in dosage level and an improved side effect profile.

Chemical Properties

Colourless, Crystalline Solid

Uses

A nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer

General Description

(S)-(+)-Ibuprofen is the enantiomer associated with the anti-inflammatory action of ibuprofen, which is widely used as a nonsteroidal anti-inflammatory drug in racemic form.

Biological Activity

Non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase 1 and cyclooxygenase 2 (IC 50 values are 12 and 80 μ M respectively). Active isomer of ibuprofen.

Purification Methods

Crystallise the (+) and (-) acids from EtOH or aqueous EtOH. The racemate which crystallises from pet ether with m 75-77o is sparingly soluble in H2O and has IR (film) 1705 (C=O), 2300—3700 (OH broad)cm-1. It is used as a non-steroidal anti-inflammatory. [Shiori et al. J Org Chem 43 2936 1978, Kaiser et al. J Pharm Sci 65 269 1976, J Pharm Sci 81 221 1992, Freer Acta Cryst (C) 49 1378 1993 for the (S+)-enantiomer.]

(S)-(+)-Ibuprofen Preparation Products And Raw materials

Raw materials

1-DEOXY-1-(OCTYLAMINO)-D-GLUCITOL (R)-(+)-4-Isopropyl-2-oxazolidinone

Preparation Products

(S)-(+)-Ibuprofen Suppliers

Global( 374)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
AVD pharmaceuticals Pvt Ltd	+919860835260	Pune, India	102	58	Inquiry
SMS Pharmaceuticals Ltd	+91-8179850881 +91-9100092121	Telangana, India	22	58	Inquiry
Arch Pharmalabs Ltd	+91-2242871210 +91-2242871210	Maharashtra, India	51	58	Inquiry
Adani Wilmar Limited	+91-7383819375 +91-9099656790	Gujarat, India	34	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
IOL Chemicals And Pharmaceuticals Limited	+91-9878429978 +91-9878996045	Punjab, India	30	58	Inquiry
Noven Lifesciences Pvt Limited	+91-9030209898 +91-9848878833	Telangana, India	21	58	Inquiry
AKASH PHARMA EXPORTS	+91-9388123451 +91-9846039283	Kerela, India	470	58	Inquiry
Festiva Pharma	08048372775Ext 728	Gujarat, India	238	58	Inquiry
Kavya Pharma	08048981075	Gujarat, India	55	58	Inquiry

Supplier	Advantage
AVD pharmaceuticals Pvt Ltd	58
SMS Pharmaceuticals Ltd	58
Arch Pharmalabs Ltd	58
Adani Wilmar Limited	58
Ralington Pharma	58
IOL Chemicals And Pharmaceuticals Limited	58
Noven Lifesciences Pvt Limited	58
AKASH PHARMA EXPORTS	58
Festiva Pharma	58
Kavya Pharma	58

(S)-(+)-Ibuprofen Spectrum

(S)-(+)-Ibuprofen(51146-56-6)MS (S)-(+)-Ibuprofen(51146-56-6)¹HNMR (S)-(+)-Ibuprofen(51146-56-6)¹³CNMR (S)-(+)-Ibuprofen(51146-56-6)IR1 (S)-(+)-Ibuprofen(51146-56-6)IR2 (S)-(+)-Ibuprofen(51146-56-6)Raman

51146-56-6((S)-(+)-Ibuprofen )Related Search:

Imidocarb dipropionate Isobutyl nitrite IBUPROFEN,α-Methyl-4-(isobutyl)phenylacetic acid, Ibuprofen,Ibuprofen (FDA),rac Ibuprofen,R,S-Ibuprofen,(+/-)-IBUPROFEN 1-Bromo-2-methylpropane α-Lipoic Acid

Propionic acid Nandrolone phenylpropionate 3-(4-Hydroxyphenyl)propionic acid Ethyl 2-(Chlorosulfonyl)acetate PHENYL VALERATE

3-Phenylpropionic acid Isobutylbenzene Propionic anhydride Phenylacetic acid isobutyl ester Ascoric Acid

IBUPROFEN IMPURITY E,IBUPROFEN IMP E IBUPROFEN IMP D,IBUPROFEN IMPURITY D IBUPROFEN IMPURITY J

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(S)-(+)-2-(4-ISOBUTYLPHENYL)PROPIONIC ACID (S)-(+)-4-ISOBUTYL-ALPHA-METHYLPHENYLACETIC ACID (S)-(+)-IBUPROFEN (2s)-2-[4-(2-methylpropyl)phenyl]propionic acid (S)-(+)-Ibuprofen ReagentPlus(R), 99% (S)-2-(4-Isobutylphenyl)propanoic acid, 95+% (S)-((addition))-Ibuprofen (S)-(+)-4-Isobutyl-a-methylphenylacetic acid S(+)-IBUPROFEN ACTIVE ISOMER OF IBUP (+)-(S)-p-Isobutylhydratropic acid (S)-(+)-4-Isobutyl-α-methylphenylacetic acid (S)-2-(p-Isobutylphenyl)propionic acid Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (S)- Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, (αS)- d-Ibuprofen Seractil S(+)-IBUPROFENE [αS,(+)]-α-Methyl-4-(2-methylpropyl)benzeneacetic acid (S)-(+)-Ibuprofen,99% s(+)-2-(4-isobutylphenyl)propionic (aS)-a-Methyl-4-(2-methylpropyl)benzeneacetic Acid (S)-(+)-2-(4-Isobutylphenyl)propionic acid, (S)-(+)-4-Isobutyl-α-methylphenylacetic acid (S)-(+)-Ibuprofen, 99% 1GR (S)-(+)-Ibuprofen (S)-(+)-4-Isobutyl-alpha-methylphenylacetic Acid (S)-(+)-Ibuprofen, 98.5% (S)-(+)-IbuprofenALPHA-METHYLPHENYLACETICACID Dex-ibuprofen (S-ibuprofen) (S)-(+)-IbuprofenQ: What is (S)-(+)-Ibuprofen Q: What is the CAS Number of (S)-(+)-Ibuprofen Q: What is the storage condition of (S)-(+)-Ibuprofen (S)-(+)-Ibuprofen, 98.5%, COX inhibitor Ibuprofen Impurity 21((S)-Isomer) RaMelteon iMpurity G Ramelteon-7 Ramelteon Imputiry G (S)-( )-Ibuprofen ((S)-Ibuprofen) (S)-(+)-ibuprofen reference substance (S)-(+)-2-(4-Isobutylphenyl)propionicAcid> (S)-2-(4-IsobutyL Ibuprofen (S)-Isomer DEXIBUPROFEN (S)-IBUPROFEN (S)-2-(4-Isobutylphenyl)propanoic acid Dextral ibuprofen Dexibuprofen (free acid)，(S)-(+)-Ibuprofen exibuprofen Dextroibuprofen (+)-Ibuprofen Deibuprofen Dextrobuprofen 51146-56-6 511406-56-6 Cyclooxygenase Inhibitors Enzymes, Inhibitors, and Substrates Organic Building Blocks Biochemicals and Reagents Application Index Chiral Building Blocks Cell Signaling Enzymes Carboxylic Acids