(S)-(+)-Ibuprofen
(S)-(+)-Ibuprofen
- CAS:
- 51146-56-6
- MF:
- C13H18O2
- MW:
- 206.28
Suppliers by country/region
Company Type
Properties
- Melting point:
- 49-53 °C(lit.)
- alpha
- 57 º (c=2, EtOH)
- Boiling point:
- 285.14°C (rough estimate)
- Density
- 1.0364 (rough estimate)
- refractive index
- 59 ° (C=2, EtOH)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.5 mg/mL
- form
- solid
- pka
- 4.41±0.10(Predicted)
- color
- white
- optical activity
- [α]20/D +59°, c = 2 in ethanol
- Water Solubility
- insoluble
- BRN
- 3590022
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- HEFNNWSXXWATRW-JTQLQIEISA-N
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319
- Precautionary statements
- P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
- Hazard Codes
- Xn
- Risk Statements
- 63-22
- Safety Statements
- 45-36/37
- WGK Germany
- 3
- HS Code
- 29163990
Use
Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, μM, respectively). It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form. (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 μM, respectively). However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 μM). A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.
27 India supplier list of "(S)-(+)-Ibuprofen "
- Product Name:S-Ibuprofen
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Telangana,INDIA
- Product Name:Dexibuprofen
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Pune,INDIA
- Product Name:S-Ibuprofen
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Reagent
- Country/Region: Gujarat,INDIA
- Product Name:S-Ibuprofen
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Punjab,INDIA
- Product Name:Dex-Ibuprofen
- Products Intro:Purity: 99% | Package: 1kg,5 kg, 10 kg,25kg and 1 MT
- Company Type: Manufacturer
- Country/Region: Kerela,INDIA
- Product Name:S-Ibuprofen
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg And 1MT
- Company Type: Manufacturer
- Country/Region: Telangana,INDIA
- Product Name:S-Ibuprofen
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Maharashtra,INDIA
- Product Name:S-Ibuprofen
- Products Intro:Purity: 98% | Package: 1 kg,5 kg, 10 kg,25kg
- Company Type: Manufacturer
- Country/Region: Gujarat,INDIA
- Product Name:(S)-(+)-Ibuprofen
- Products Intro:Brand:sigma aldrich | Product Number:375160 | Purity:ReagentPlus?,99%
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:(S)-(+)-Ibuprofen
- Company Type: Reagent
- Country/Region: Pune,INDIA