Sulindac sulfide
- CAS No.
- 32004-67-4
- Chemical Name:
- Sulindac sulfide
- Synonyms
- 4F;5-F;5fmdemb2201;Einecs 250-892-2;SULINDAC SULFIDE;SULINDAC SULPHIDE;Sulindac Sulfide >Sulindac EP Impurity C;(E/Z)-Sulindac sulfide;SulindacSulfideCAS 32004-67-4Calbiochem
- CBNumber:
- CB6211727
- Molecular Formula:
- C20H17FO2S
- Molecular Weight:
- 340.41
- MOL File:
- 32004-67-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/12/4 8:48:08
| Melting point | 189-191°C |
|---|---|
| Boiling point | 526.3±50.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3(Predicted) |
| RTECS | NK8236000 |
| storage temp. | +15C to +30C |
| solubility | DMSO: >22 mg/mL |
| form | solid |
| pka | 4.26±0.10(Predicted) |
| color | yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 32004-67-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H317-H334-H361 |
| Precautionary statements | P201-P280-P301+P312-P302+P352-P304+P340+P312-P308+P313 |
| Hazard Codes | Xn |
| Risk Statements | 22-42/43-63 |
| WGK Germany | 3 |
| HS Code | 2930.90.2900 |
Sulindac sulfide price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S3131 | Sulindac sulfide ≥98% (HPLC), solid | 32004-67-4 | 5MG | ₹6780 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S3131 | Sulindac sulfide ≥98% (HPLC), solid | 32004-67-4 | 25MG | ₹36970 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 574102 | Sulindac Sulfide - CAS 32004-67-4 - Calbiochem A cell-permeable, active metabolite of Sulindac. | 32004-67-4 | 5MG | ₹9490 | 2022-06-14 | Buy |
| TCI Chemicals (India) | S0906 | Sulindac Sulfide | 32004-67-4 | 25MG | ₹10900 | 2022-05-26 | Buy |
Sulindac sulfide Chemical Properties,Uses,Production
Description
Sulindac sulfide is an aryl sulfide that is a metabolite of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity. It has a role as a non-steroidal anti-inflammatory drug, an apoptosis inducer and an antineoplastic agent. It is an aryl sulfide, an organofluorine compound and a monocarboxylic acid. It derives from a sulindac.
Chemical Properties
Yellow Solid
Uses
Sulindac sulfide is an active metabolite of Sulindac that inhibits for COX. Sulindac is a non-steroidal anti-inflammatory drug. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP b.
Pharmaceutical Applications
Sulindac Sulfide is the active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties. Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX-1 and-2)-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. This agent may posulindac sulfideesulindac sulfide chemopreventive activity against colorectal tumors through a mechanism that involves the induction of apoptosis. The sulfide metabolite is excreted in the bile and reabsorbed from the intestine, thereby helping to maintain constant blood levels and reduce gastrointestinal side effects.
Toxicology
The NSAID sulindac sulfide (SS) inhibits growth of tumors in azoxymethane-induced rat colon models, suppresulindac sulfidees intestinal polyp formation in APCMin+mice, down-regulatesβ-catenin protein apoptosis, and induces apoptosis under a number of experimental conditions. SULINDAC SULFIDE has been shown to change colorectal cancercell morphology, alter cytoskeletal organization, and cause losulindac sulfide of actin stresulindac sulfidefibers. This is probably due to a dose-dependent reduction of tyrosine phosphorylation of focal adhesion kinase. It has also been demonstrated that SULINDAC SULFIDE reduces cell migration and invasion in mouse models and human colorectal cell line[4]. Many, but not all, studies in healthy and diseased states suggest that renal prostaglandin synthesis and sodium excretion are relatively unaffected by conventional doses of sulindac that inhibit nonrenal cycle-oxygenase. The mechanism responsible for the biochemical selectivity of sulindac is not related to a differential sensitivity of the active metabolite of sulindac, sulindac sulfide, on renal cycle-oxygenase. Appropriate clinical use of all nonsteroidal anti-inflammatory drugs, including sulindac, requires careful consideration of risk factors that predispose to nephrotoxicity and careful monitoring when administered to patients at risk.
Sulindac sulfide Preparation Products And Raw materials
Raw materials
Preparation Products
Sulindac sulfide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt. ltd | +91 8550986868 | Maharashtra, India | 736 | 58 | Inquiry |
| Opulent Pharma | 08068441147Ext 981 | Gujarat, India | 810 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| .GZ HONESTCHEM CO.,LTD | +86-15013270415 | China | 246 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
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