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ChemicalBook > Product Catalog >API >Antipyretic analgesics >Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >MECLOFENAMATE SODIUM

MECLOFENAMATE SODIUM

MECLOFENAMATE SODIUM Structure
CAS No.
6385-02-0
Chemical Name:
MECLOFENAMATE SODIUM
Synonyms
ci583;C02996;Movens;meclomen;Meclonax;Meclofenamate;sodiummeclophenamate;SODIUM MECLOFENAMATE;MECLOFENAMATE SODIUM;MECLOFENAMATESODIUM,USP
CBNumber:
CB7102365
Molecular Formula:
C14H10Cl2NO2.Na
Molecular Weight:
318.13
MOL File:
6385-02-0.mol
MSDS File:
SDS
Modify Date:
2023/7/21 17:23:12
Request For Quotation

MECLOFENAMATE SODIUM Properties

Melting point 287-291 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
form White solid.
color White to Off-White
Water Solubility Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
Merck 14,5779
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
WGK Germany  3
RTECS  CB2975500
HS Code  2922498050
NFPA 704
0
3 0

MECLOFENAMATE SODIUM price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) M4531 Meclofenamic acid sodium salt 6385-02-0 1G ₹5542.4 2022-06-14 Buy
Sigma-Aldrich(India) M4531 Meclofenamic acid sodium salt 6385-02-0 5G ₹16529.78 2022-06-14 Buy
TCI Chemicals (India) M1269 Sodium Meclofenamate 6385-02-0 1G ₹3400 2022-05-26 Buy
TCI Chemicals (India) M1269 Sodium Meclofenamate 6385-02-0 10G ₹20500 2022-05-26 Buy
Product number Packaging Price Buy
M4531 1G ₹5542.4 Buy
M4531 5G ₹16529.78 Buy
M1269 1G ₹3400 Buy
M1269 10G ₹20500 Buy

MECLOFENAMATE SODIUM Chemical Properties,Uses,Production

Description

Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.

Uses

Meclofenamate Sodium is an NSAID used in the treatment of chronic pain.

Definition

ChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.

Indications

Meclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.

General Description

Meclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.

Pharmacokinetics

Meclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours. Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation. Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of 3′-methyl oxidation and has been shown to possess anti-inflammatory activity.
Metabolism of meclofenamic acid..jpg

Clinical Use

Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.

MECLOFENAMATE SODIUM Preparation Products And Raw materials

Raw materials

2,6-Dichloro-3-methylaniline N-Ethylmorpholine

Preparation Products

MECLOFENAMATE SODIUM Suppliers

Global( 115)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Aurazia Chem Laboratories Private Limited +91-9840924287 +91-8754492844 Tamil Nadu, India 29 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Auraziachem Laboraotories Private Limited 91-8754492844 Tamil Nadu, India 20 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25910 58 Inquiry
Supplier Advantage
Aurazia Chem Laboratories Private Limited 58
TCI Chemicals (India) Pvt. Ltd. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
Auraziachem Laboraotories Private Limited 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58

MECLOFENAMATE SODIUM Spectrum

MECLOFENAMATE SODIUM(6385-02-0)1HNMRMECLOFENAMATE SODIUM(6385-02-0)13CNMRMECLOFENAMATE SODIUM(6385-02-0)IR1MECLOFENAMATE SODIUM(6385-02-0)IR2

6385-02-0(MECLOFENAMATE SODIUM)Related Search:

MCPA SODIUM CLOFENAMIC ACID SODIUM ANTHRANILATE Meclofenamic acid MECLOFENAMATE SODIUM
N-Phenylanthranilic acid 2,6-DICHLORODIPHENYLAMINE 2-Chloro-5-methylaniline 2,6-Dichloro-3-methylaniline 2-Chloro-m-toluidine.
N-(2-CHLOROPHENYL)ANTHRANILIC ACID N-(3-METHYLPHENYL)ANTHRANILIC ACID 2-[(2-Chlorophenyl)amino]-benzaldehyde 2-[(2,6-dichlorophenyl)amino]benzoicacid (2-CHLORO-PHENYL)-PHENYL-AMINE
(2-(2,6-DICHLOROANILINO)PHENYL) METHANOL 2-(2,6-Dichloroanilino) benzaldehyde MECLOFENAMATE SODIUM USP(CRM STANDARD)
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MECLOFENAMIC ACID SODIUM SALT MONOHYDRATE Sodium Meclofenamate Monohydrate C02996 SODIUM MECLOFENAMATE meclofenamic acid sodium MECLOFENAMIC ACID SODIUM SALT 99% Meclofenamate MECLOFENAMATESODIUM,USP sodium meclofenamate (anhydrous) sodium2-((2,6-dichloro-3-methylphenyl)amino)benzoate sodiummeclophenamate MECLOFENAMATE SODIUM MECLOFENAMATE SODIUM HYDRATE MECLOFENAMATE SODIUM SALT MECLOFENAMIC ACID SODIUM SALT 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]-BENZOIC ACID, MONOSODIUM SALT 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]BENZOIC ACID SODIUM SALT sodium,2-(2,6-dichloro-3-methylanilino)benzoate 2-((2,6-dichloro-3-methylphenyl)amino)-benzoicacimonosodiumsalt ci583 meclomen n-(2,6-dichloro-m-tolyl)-anthranilicacimonosodiumsalt Benzoic acid, 2-[(2,6-dichloro-3-Methylphenyl)aMino]-, sodiuM salt Meclofenamate Sodium (500 mg) 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic Acid Sodium Salt Meclofenamic Acid Sodium Salt SodiuM MeclofenaMate  Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, sodium salt (1:1) 2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, sodium salt (1:1) Sodium Meclofenamate Hydrate sodium 2-(2,6-dichloro-3-methylanilino)benzoate hydrate SodiumMeclofenamateMonohydrate> Meclonax Movens 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt monohydrate MECLOFENAMATE SODIUM USP/EP/BP Meclofenamate Sodium (Meclofenamic acid sodium) Meclofenamate Sodium (1377803) Endogenous Metabolite,Meclofenamate,Inhibitor,Meclofenamic acid sodium,inhibit,Meclofenamic acid,Gap Junction Protein Sodium Meclofenamate Monohydrate, ≥ 98.0% 6385-02-0 6358-02-0 C14H10Cl2NO2NaH2O C14H10Cl2NNaO2H2O C14H10Cl2NNaO2xH2O C14H11Cl2NNaO2 Lipoxygenase (5-) and cyclooxygenase L to O Enzyme Inhibitors Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates BioChemical Biochemicals and Reagents MECLOMEN