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SR 0987

SR 0987 Structure
CAS No.
303126-97-8
Chemical Name:
SR 0987
Synonyms
SR 0987;SR0987 >=98% (HPLC);SR0987, 10 mM in DMSO;SR 0987;SR-0987;SR0987;303126-97-8;SR0987,ROR,SR-0987,Inhibitor,SR 0987,inhibit,RAR-related orphan receptor;2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide;2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide;Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
CBNumber:
CB13152747
Molecular Formula:
C16H10ClF6NO2
Molecular Weight:
397.7
MOL File:
303126-97-8.mol
Modify Date:
2025/1/27 9:38:02
Request For Quotation

SR 0987 Properties

Boiling point 378.8±42.0 °C(Predicted)
Density 1.525±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml)
pka 9.22±0.15(Predicted)
form solid
color White
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

SR 0987 Chemical Properties,Uses,Production

Description

SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA and ionomycin , increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987.

Uses

SR 0987 is a RORγt agonist.

SR 0987 Preparation Products And Raw materials

Raw materials

Preparation Products

SR 0987 Suppliers

Global( 58)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
TargetMol Chemicals Inc. United States 38630 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43340 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 China 42056 58 Inquiry
Aladdin Scientific United States 57505 58 Inquiry
DC Chemicals 021-58447131 13564518121 China 9409 58 Inquiry
Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
LEAPCHEM CO., LTD. 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
Aladdin Scientific 58
DC Chemicals 58

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SR 0987 2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide 2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide SR 0987;SR-0987;SR0987;303126-97-8 Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]- SR0987 >=98% (HPLC) SR0987,ROR,SR-0987,Inhibitor,SR 0987,inhibit,RAR-related orphan receptor SR0987, 10 mM in DMSO 303126-97-8 C16H10ClF6NO2 API