SRPK inhibitor

SRPK inhibitor Structure
CAS No.
218156-96-8
Chemical Name:
SRPK inhibitor
Synonyms
CS-910;SRPIN340;SRPIN 340;SRPIN-340;SRPK inhibitor;SRPIN340, >=98%;SRPIN340 >=98% (HPLC);SRPK Inhibitor(SRPIN340);SRPIN340 (SRPK inhibitor);SRPIN 340; SRPIN-340; SRPK INHIBITOR
CBNumber:
CB22668305
Molecular Formula:
C18H18F3N3O
Molecular Weight:
349.35
MOL File:
218156-96-8.mol
MSDS File:
SDS
Modify Date:
2023/9/4 15:51:00

SRPK inhibitor Properties

Boiling point 395.9±42.0 °C(Predicted)
Density 1.306±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble20mg/mL, clear
form powder
pka 11.09±0.70(Predicted)
color white to beige
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

SRPK inhibitor price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML1088 SRPIN340 ≥98% (HPLC) 218156-96-8 5MG ₹11009.03 2022-06-14 Buy
Sigma-Aldrich(India) SML1088 SRPIN340 ≥98% (HPLC) 218156-96-8 25MG ₹44339.2 2022-06-14 Buy
Sigma-Aldrich(India) 5.04293 SRPK Inhibitor, SRPIN340 - CAS 281856-96-8 - Calbiochem 218156-96-8 10MG ₹17660.01 2022-06-14 Buy
Product number Packaging Price Buy
SML1088 5MG ₹11009.03 Buy
SML1088 25MG ₹44339.2 Buy
5.04293 10MG ₹17660.01 Buy

SRPK inhibitor Chemical Properties,Uses,Production

Description

Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1. SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. SRPIN340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. By blocking SRPK1-mediated phosphorylation of SRSF1, SRPIN340 modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.

Uses

SRPIN340 is a SRPK1 kinase inhibitor, which shows potential novel targeted therapeutic strategy in prostate cancer.

SRPK inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 117)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29900 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Coresyn Pharmatech Co., Ltd. +86-571-86626709 +86-18157142896 China 9991 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry

SRPK inhibitor Spectrum

4-Pyridinecarboxamide, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]- N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPIN 340 SRPK inhibitor N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPIN 340 SRPIN340 SRPIN-340 SRPK inhibitor N-(2-(piperidin-1-yl)-5-(trifluoroMethyl)phenyl)isonicotinaMide N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPK Inhibitor(SRPIN340) SRPIN340, >=98% N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide CS-910 SRPIN 340; SRPIN-340; SRPK INHIBITOR SRPIN340 >=98% (HPLC) SRPIN340 (SRPK inhibitor) 218156-96-8 Inhibitors