SRPK inhibitor
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- ₹11009.03 - ₹44339.2
- Product name: SRPK inhibitor
- CAS: 218156-96-8
- MF: C18H18F3N3O
- MW: 349.35
- EINECS:
- MDL Number:MFCD00116244
- Synonyms:4-Pyridinecarboxamide, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-;N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPIN 340;SRPK inhibitor N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide;SRPIN 340;SRPIN340;SRPIN-340;SRPK inhibitor;N-(2-(piperidin-1-yl)-5-(trifluoroMethyl)phenyl)isonicotinaMide
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1088
- Product descriptionSRPIN340 ≥98% (HPLC)
- Packaging5MG
- Price₹11009.03
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number5.04293
- Product descriptionSRPK Inhibitor, SRPIN340 - CAS 281856-96-8 - Calbiochem
- Packaging10MG
- Price₹17660.01
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1088
- Product descriptionSRPIN340 ≥98% (HPLC)
- Packaging25MG
- Price₹44339.2
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1088 | SRPIN340 ≥98% (HPLC) | 5MG | ₹11009.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.04293 | SRPK Inhibitor, SRPIN340 - CAS 281856-96-8 - Calbiochem | 10MG | ₹17660.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1088 | SRPIN340 ≥98% (HPLC) | 25MG | ₹44339.2 | 2022-06-14 | Buy |
Properties
Boiling point :395.9±42.0 °C(Predicted)
Density :1.306±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :11.09±0.70(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Density :1.306±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :11.09±0.70(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1. SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. SRPIN340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. By blocking SRPK1-mediated phosphorylation of SRSF1, SRPIN340 modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.More related product prices
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