SR8278
|
- ₹16107.6 - ₹64841.75
- Product name: SR8278
- CAS: 1254944-66-5
- MF: C18H19NO3S2
- MW: 361.48
- EINECS:
- MDL Number:MFCD18782736
- Synonyms:SR8278;1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester;UIEBLUZPSFAFOC-UHFFFAOYSA-N;SR8278;SR-8278;SR 8278;ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate;Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate;3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-, ethyl ester;Duchenne muscular dystrophy,inhibit,metabolism,biological rhythm,Alzheimer's disease,SR-8278,SR8278,neurosurgery,Inhibitor,REV-ERBα,SR 8278,REV-ERB
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberS9576
- Product descriptionSR8278 ≥98% (HPLC)
- Packaging25MG
- Price₹64841.75
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberS9576
- Product descriptionSR8278 ≥98% (HPLC)
- Packaging5MG
- Price₹16107.6
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S9576 | SR8278 ≥98% (HPLC) | 25MG | ₹64841.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S9576 | SR8278 ≥98% (HPLC) | 5MG | ₹16107.6 | 2022-06-14 | Buy |
Properties
Melting point :52-55°C
Boiling point :535.7±50.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥30mg/mL
pka :-3.20±0.40(Predicted)
form :film
color :white to tan
Boiling point :535.7±50.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥30mg/mL
pka :-3.20±0.40(Predicted)
form :film
color :white to tan
Safety Information
| Symbol(GHS): | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | |||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.More related product prices
SR 0987 N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine SR17018 SR27897 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide SR 1078 SRPK inhibitor SR-9243 SR9009 2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamideRelated product price
- N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
₹29860 - SRPK inhibitor
₹11009.03-44339.2 - SR9009
₹15910
Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Career Henan Chemica Co
InvivoChem
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
LEAPCHEM CO., LTD.
Shanghai Acmec Biochemical Technology Co., Ltd.
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd