SR 0987
- ₹0
- Product name: SR 0987
- CAS: 303126-97-8
- MF: C16H10ClF6NO2
- MW: 397.7
- EINECS:
- MDL Number:MFCD02693203
- Synonyms:SR 0987;2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide;2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide;SR 0987;SR-0987;SR0987;303126-97-8;Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-;SR0987 >=98% (HPLC);SR0987,ROR,SR-0987,Inhibitor,SR 0987,inhibit,RAR-related orphan receptor
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Properties
Boiling point :378.8±42.0 °C(Predicted)
Density :1.525±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml)
pka :9.22±0.15(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Density :1.525±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml)
pka :9.22±0.15(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety Information
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Description
SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA and ionomycin , increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987.More related product prices
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