SR 1078
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- Product name: SR 1078
- CAS: 1246525-60-9
- MF: C17H10F9NO2
- MW: 431.25
- EINECS:
- MDL Number:MFCD18782737
- Synonyms:N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide;SR 1078;SR1078,N-[4-(2,2,2-Trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenyl]-4-trifluoroMethyl-benzaMide;N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide SR1078;SR1078;SR 1078;SR-1078;N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]-4-(trifluoromethyl)benzamide;SR1078,N-[4-(2,2,2-TRIFLUORO-1-HYDROXY-1-TRIFLUOROMETHYL-ETHYL)-PHENYL]-4-TRIFLU;SR 1078; SR-1078
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Properties
Melting point :169℃
Boiling point :362.9±42.0 °C(Predicted)
Density :1.527±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO, Methanol (Slightly)
form :Solid
pka :9.21±0.15(Predicted)
color :Off-White
Boiling point :362.9±42.0 °C(Predicted)
Density :1.527±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO, Methanol (Slightly)
form :Solid
pka :9.21±0.15(Predicted)
color :Off-White
Safety Information
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Description
Retinoic acid receptor-related orphan receptors α and γ (RORα and RORγ) have been demonstrated to play important roles in the regulation of metabolism, circadian rhythms, immune function, and tumorigenesis. SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 μM without effect at the related liver X receptors and farnesoid X receptors. At 5 μM, SR 1078 has been shown to stabilize p53 and to induce apoptosis in HepG2 cancer cells.More related product prices
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