SR-9243
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- ₹0
- Product name: SR-9243
- CAS: 1613028-81-1
- MF: C31H32BrNO4S2
- MW: 626.62
- EINECS:-0
- MDL Number:MFCD29049514
- Synonyms:SR-9243;N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide;N-(3-bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide;Benzenesulfonamide, N-[2-(3-bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]-;CS-1645;SR 9243;SR9243;SR-9243;N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-;N-(3-Bromophenethyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide
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Properties
Melting point :154-155°C
Boiling point :786.3±70.0 °C(Predicted)
Density :1.347±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (greater than 25 mg/ml)
pka :-6.90±0.70(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Boiling point :786.3±70.0 °C(Predicted)
Density :1.347±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (greater than 25 mg/ml)
pka :-6.90±0.70(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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Description
The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors. They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9243 is a cell-permeable LXR inverse agonist that induces LXR-corepressor interaction at nanomolar concentrations. It reduces cancer cell viability (IC50 values range from 15 to 104 nM) without cytotoxicity against non-malignant cells. SR9243 disrupts the Warburg effect in cancer cells, suppressing the expression of glycolytic and lipogenic genes and reducing glycolytic metabolites and lipid production. It is effective in vivo, blocking glycolytic and lipogenic gene expression and inducing apoptosis in colon cancer xenografts without inducing weight loss in mice.More related product prices
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Career Henan Chemica Co
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Zibo Hangyu Biotechnology Development Co., Ltd
LEAPCHEM CO., LTD.
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd