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SRPK inhibitor

SRPK inhibitor structure

CAS No.: 218156-96-8

Chemical Name:: SRPK inhibitor

Synonyms: CS-910;SRPIN340;SRPIN 340;SRPIN-340;SRPK inhibitor;SRPIN340, >=98%;SRPIN340 >=98% (HPLC);SRPK Inhibitor(SRPIN340);SRPIN340 (SRPK inhibitor);SRPIN 340; SRPIN-340; SRPK INHIBITOR

CBNumber:: CB22668305

Molecular Formula:: C18H18F3N3O

Molecular Weight:: 349.35

MDL Number:: MFCD00116244

MOL File:: 218156-96-8.mol

MSDS File:: SDS

Last updated:2024-11-19 20:33:22

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SRPK inhibitor Properties

Boiling point	395.9±42.0 °C(Predicted)
Density	1.306±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble20mg/mL, clear
form	powder
pka	11.09±0.70(Predicted)
color	white to beige
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

Hazard Codes

Risk Statements

WGK Germany

NFPA 704

	0
2		0

SRPK inhibitor price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1088	SRPIN340 ≥98% (HPLC)	218156-96-8	5mg	$118	2024-03-01	Buy
Sigma-Aldrich	SML1088	SRPIN340 ≥98% (HPLC)	218156-96-8	25mg	$476	2024-03-01	Buy
Sigma-Aldrich	5.04293	SRPK Inhibitor, SRPIN340 - CAS 281856-96-8 - Calbiochem	218156-96-8	10mg	$204	2023-01-07	Buy
Cayman Chemical	16284	SRPIN340 ≥95%	218156-96-8	1mg	$32	2024-03-01	Buy
Cayman Chemical	16284	SRPIN340 ≥95%	218156-96-8	5mg	$86	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1088	5mg	$118	Buy
SML1088	25mg	$476	Buy
5.04293	10mg	$204	Buy
16284	1mg	$32	Buy
16284	5mg	$86	Buy

SRPK inhibitor Chemical Properties,Uses,Production

Description

Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1. SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (K_i = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. SRPIN340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. By blocking SRPK1-mediated phosphorylation of SRSF1, SRPIN340 modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.

Uses

SRPIN340 is a SRPK1 kinase inhibitor, which shows potential novel targeted therapeutic strategy in prostate cancer.

References

1) Fukuhara?et al.?(2006),?Utilization of host SR protein kinases and RNA-splicing machinery during viral replication; Proc. Natl. Acad. Sci. USA,?103?11329 2) Gammons?et al.?(2013),?SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity; Invest. Ophthalmol. Vis. Sci.,?54?5797 3) Gammons?et al.?(2014),?Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma; Br. J. Cancer,?111?477

SRPK inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

SRPK inhibitor Suppliers

Global( 115)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
BOC Sciences	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
Shenzhen Shengda Pharma Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

View Lastest Price from SRPK inhibitor manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	SRPIN340 218156-96-8	US $39.00-107.00 / mg		99.96%	10g	TargetMol Chemicals Inc.
	2019-09-06	SRPK inhibitor 218156-96-8	US $1.00 / KG	1KG	98%	20kg	Career Henan Chemical Co

SRPIN340
218156-96-8
US $39.00-107.00 / mg
99.96%
TargetMol Chemicals Inc.

SRPK inhibitor
218156-96-8
US $1.00 / KG
98%
Career Henan Chemical Co

SRPK inhibitor Spectrum

SRPK inhibitor(218156-96-8)¹HNMR

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4-Pyridinecarboxamide, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]- N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPIN 340 SRPK inhibitor N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPIN 340 SRPIN340 SRPIN-340 SRPK inhibitor N-(2-(piperidin-1-yl)-5-(trifluoroMethyl)phenyl)isonicotinaMide N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPK Inhibitor(SRPIN340) SRPIN340, >=98% N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide CS-910 SRPIN 340; SRPIN-340; SRPK INHIBITOR SRPIN340 >=98% (HPLC) SRPIN340 (SRPK inhibitor) 218156-96-8 Inhibitors