- SRPK inhibitor
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- $1.00 / 1KG
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2019-09-06
- CAS:218156-96-8
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 20kg
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| | SRPK inhibitor Basic information |
| Product Name: | SRPK inhibitor | | Synonyms: | 4-Pyridinecarboxamide, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-;N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPIN 340;SRPK inhibitor N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide;SRPIN 340;SRPIN340;SRPIN-340;SRPK inhibitor;N-(2-(piperidin-1-yl)-5-(trifluoroMethyl)phenyl)isonicotinaMide | | CAS: | 218156-96-8 | | MF: | C18H18F3N3O | | MW: | 349.35 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 218156-96-8.mol |  |
| | SRPK inhibitor Chemical Properties |
| Boiling point | 395.9±42.0 °C(Predicted) | | density | 1.306±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble20mg/mL, clear | | form | powder | | pka | 11.09±0.70(Predicted) | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | SRPK inhibitor Usage And Synthesis |
| Description | Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1. SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. SRPIN340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. By blocking SRPK1-mediated phosphorylation of SRSF1, SRPIN340 modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals. | | Uses | SRPIN340 is a SRPK1 kinase inhibitor, which shows potential novel targeted therapeutic strategy in prostate cancer. | | References | 1) Fukuhara?et al.?(2006),?Utilization of host SR protein kinases and RNA-splicing machinery during viral replication; Proc. Natl. Acad. Sci. USA,?103?11329
2) Gammons?et al.?(2013),?SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity; Invest. Ophthalmol. Vis. Sci.,?54?5797
3) Gammons?et al.?(2014),?Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma; Br. J. Cancer,?111?477 |
| | SRPK inhibitor Preparation Products And Raw materials |
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