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| Product Name: | SR-717 | | Synonyms: | SR-717;SR171;SR-717 lithium;SR 717 (lithium salt);immunity,MPYS,MITA,inhibit,ISG-THP1,Inhibitor,SR 717,mimetic,TMEM173,STING,SR717,cGAMP,THP1,antitumor,ERIS,SR-717,PD-L1,Stimulator of Interferon Genes;Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate;SR171&SR-717 lithium | | CAS: | 2375421-09-1 | | MF: | C15H10F2LiN5O3 | | MW: | 353.21 | | EINECS: | | | Product Categories: | | | Mol File: | 2375421-09-1.mol |  |
| | SR-717 Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in DMSO (>25 mg/ml) | | form | solid | | color | Off-white | | Water Solubility | Water: < 0.1 mg/mL (insoluble) | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1. |
| | SR-717 Usage And Synthesis |
| Description | SR-717 (2375421-09-1) is a cell permeable and exceptionally selective STING agonist (IC50 = 7.8 μM).? It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC’s. | | References | Chin et al. (2020), Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic; Science 369 993 |
| | SR-717 Preparation Products And Raw materials |
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