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| | SR 0987 Basic information |
| Product Name: | SR 0987 | | Synonyms: | SR 0987;2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide;2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide;SR 0987;SR-0987;SR0987;303126-97-8;Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-;SR0987 >=98% (HPLC);SR0987,ROR,SR-0987,Inhibitor,SR 0987,inhibit,RAR-related orphan receptor | | CAS: | 303126-97-8 | | MF: | C16H10ClF6NO2 | | MW: | 397.7 | | EINECS: | | | Product Categories: | API | | Mol File: | 303126-97-8.mol |  |
| | SR 0987 Chemical Properties |
| Boiling point | 378.8±42.0 °C(Predicted) | | density | 1.525±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml) | | pka | 9.22±0.15(Predicted) | | form | solid | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| | SR 0987 Usage And Synthesis |
| Description | SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA and ionomycin , increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987. | | Uses | SR 0987 is a RORγt agonist. | | storage | Store at +4°C | | References | 1) Chang?et al.?(2016),?Synthetic RORγt Agonists Enhance Protective Immunity;?ACS Chem. Biol.?11?1012 |
| | SR 0987 Preparation Products And Raw materials |
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