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| Product Name: | SR8278 | | Synonyms: | SR8278;1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester;UIEBLUZPSFAFOC-UHFFFAOYSA-N;SR8278;SR-8278;SR 8278;ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate;Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate;3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-, ethyl ester;Duchenne muscular dystrophy,inhibit,metabolism,biological rhythm,Alzheimer's disease,SR-8278,SR8278,neurosurgery,Inhibitor,REV-ERBα,SR 8278,REV-ERB | | CAS: | 1254944-66-5 | | MF: | C18H19NO3S2 | | MW: | 361.48 | | EINECS: | | | Product Categories: | 123456 | | Mol File: | 1254944-66-5.mol |  |
| | SR8278 Chemical Properties |
| Melting point | 52-55°C | | Boiling point | 535.7±50.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ≥30mg/mL | | pka | -3.20±0.40(Predicted) | | form | film | | color | white to tan |
| | SR8278 Usage And Synthesis |
| Description | REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells. | | Uses | SR 8278 is a synthetic antagonist of the nuclear heme receptor REV-ERB. | | storage | Store at +4°C |
| | SR8278 Preparation Products And Raw materials |
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