ChemicalBook >> CAS DataBase List >>SR8278
SR8278
- CAS No.
- 1254944-66-5
- Chemical Name:
- SR8278
- Synonyms
- SR8278;SR8278;SR-8278;SR 8278;UIEBLUZPSFAFOC-UHFFFAOYSA-N;ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate;Ethyl 2-(5-(methylthio)thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate;Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate;1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester;3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-, ethyl ester;Duchenne muscular dystrophy,inhibit,metabolism,biological rhythm,Alzheimer's disease,SR-8278,SR8278,neurosurgery,Inhibitor,REV-ERBα,SR 8278,REV-ERB
- CBNumber:
- CB42628428
- Molecular Formula:
- C18H19NO3S2
- Molecular Weight:
- 361.48
- MDL Number:
- MFCD18782736
- MOL File:
- 1254944-66-5.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
SR8278 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S9576 | SR8278 ≥98% (HPLC) | 1254944-66-5 | 5mg | $161 | 2024-03-01 | Buy |
| Sigma-Aldrich | S9576 | SR8278 ≥98% (HPLC) | 1254944-66-5 | 25mg | $387.6 | 2024-03-01 | Buy |
| Cayman Chemical | 17000 | SR8278 ≥90% | 1254944-66-5 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17000 | SR8278 ≥90% | 1254944-66-5 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 17000 | SR8278 ≥90% | 1254944-66-5 | 10mg | $201 | 2024-03-01 | Buy |
SR8278 Chemical Properties,Uses,Production
Description
REV-ERBα is a nuclear receptor and transcription repressor that coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. SR8278 is an antagonist of REV-ERBα (EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112 . Moreover, SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells. SR8278 has been used, with GSK 4112, to elucidate the role of REV-ERBα in regulating glucagon secretion in pancreatic alpha cells.
Uses
SR 8278 is a synthetic antagonist of the nuclear heme receptor REV-ERB.
storage
Store at +4°C
SR8278 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 84)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
1254944-66-5(SR8278)Related Search:
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SR8278
1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
UIEBLUZPSFAFOC-UHFFFAOYSA-N
SR8278;SR-8278;SR 8278
ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate
Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate
3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-, ethyl ester
Duchenne muscular dystrophy,inhibit,metabolism,biological rhythm,Alzheimer's disease,SR-8278,SR8278,neurosurgery,Inhibitor,REV-ERBα,SR 8278,REV-ERB
Ethyl 2-(5-(methylthio)thiophene-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
1254944-66-5
125944-66-5
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