2,3,4-Trihydroxybenzaldehyde
- CAS No.
- 2144-08-3
- Chemical Name:
- 2,3,4-Trihydroxybenzaldehyde
- Synonyms
- 2,3,4-Trihydroxybenazldehyde;NSC 22595;2,3,4-THB;PYROGALLOLALDEHYDE;2,3,4-TrihydroxybenzaL;Pyrogallolcarboxaldehyde;,3,4-Trihydroxybenzaldehyd;PYROGALLOL-4-CARBOXALDEHYDE;2,3,4-Trihdroxybenzaldehyde;2,3,4-TRIHYDROXYBENZALDEHYDE
- CBNumber:
- CB1396755
- Molecular Formula:
- C7H6O4
- Molecular Weight:
- 154.12
- MOL File:
- 2144-08-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/22 18:05:02
| Melting point | 159-161 °C (lit.) |
|---|---|
| Boiling point | 237.46°C (rough estimate) |
| Density | 1.3725 (rough estimate) |
| refractive index | 1.6400 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| form | Powder |
| pka | 7.41±0.23(Predicted) |
| color | Light brown to beige-brown |
| Water Solubility | 1.541g/L at 25℃ |
| Sensitive | Air Sensitive |
| BRN | 2328658 |
| LogP | 1.25 |
| CAS DataBase Reference | 2144-08-3(CAS DataBase Reference) |
| EPA Substance Registry System | Benzaldehyde, 2,3,4-trihydroxy- (2144-08-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | CU8439800 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29124990 | |||||||||
| NFPA 704 |
|
2,3,4-Trihydroxybenzaldehyde price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 260843 | 2,3,4-Trihydroxybenzaldehyde 98% | 2144-08-3 | 5G | ₹4384.13 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T2158 | 2,3,4-Trihydroxybenzaldehyde min. 98.0 % | 2144-08-3 | 5G | ₹3500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T2158 | 2,3,4-Trihydroxybenzaldehyde min. 98.0 % | 2144-08-3 | 25G | ₹8300 | 2022-05-26 | Buy |
| ALFA India | ALF-A13745-14 | 2,3,4-Trihydroxybenzaldehyde, 98% | 2144-08-3 | 25g | ₹10842 | 2022-05-26 | Buy |
| ALFA India | ALF-A13745-06 | 2,3,4-Trihydroxybenzaldehyde, 98% | 2144-08-3 | 5g | ₹4503 | 2022-05-26 | Buy |
2,3,4-Trihydroxybenzaldehyde Chemical Properties,Uses,Production
Description
2,3, 4-trihydroxybenzaldehyde is an essential intermediate of the antiparkinson drug benserazide, which is a peripheral dopa decarboxylase inhibitor, usually benserazide: the L-dopa is prepared into a compound preparation at a ratio of 1:4, and has a remarkable effect of treating the Parkinson's disease.
Chemical Properties
light brown to beige-brown powder
Uses
2,3,4-Trihydroxybenzaldehyde is a phenolic benzaldehyde with antibacterial activity.
General Description
Antimicrobial activity of carbohydrazone derived from 2,3,4-trihydroxybenzaldehyde against bacteria and fungi has been investigated. 2,3,4-trihydroxybenzaldehyde forms Schiff bases via [1+1] condensation with anthranilic acid.
Synthesis
The method for synthesizing 2,3, 4-trihydroxybenzaldehyde is shown as follows. 
This method takes pyrogallol as an initial raw material. It comprises three steps of phenolic hydroxyl protection, formylation, and deprotection: protecting two adjacent phenolic hydroxyl groups in the pyrogallol to obtain 4-hydroxybenzo[d][1,3]dioxol-2-one, then performing formylation to obtain 7-hydroxy-2-oxobenzo[d][1,3]dioxole-4-carbaldehyde, and finally removing a protecting group to get a target 2,3,4-trihydroxybenzaldehyde.
2,3,4-Trihydroxybenzaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SREE SYNERIC LAB | +91-91-6383636810 +91-9884742764 | Tamil Nadu, India | 465 | 58 | Inquiry |
| Shamrock Pharmachemi Pvt Ltd | +91-9702927092 +91-9702927092 | Mumbai, India | 19 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| PEE ESS AROMATICS | +91 4426247322 | New Delhi, India | 258 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Jiurui Biology Chemistry Co.,Ltd. | +86-0744-8561603 +8619974416182 | China | 26 | 58 | Inquiry |
| Hangzhou Benoy Chemical Co., Ltd | +8617342059697 | China | 315 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SREE SYNERIC LAB | 58 |
| Shamrock Pharmachemi Pvt Ltd | 58 |
| CHEMSWORTH | 30 |
| PEE ESS AROMATICS | 30 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Jiurui Biology Chemistry Co.,Ltd. | 58 |
| Hangzhou Benoy Chemical Co., Ltd | 58 |
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