L-Fucose
- CAS No.
- 2438-80-4
- Chemical Name:
- L-Fucose
- Synonyms
- L-(-)-FUCOSE;6-DEOXY-L-GALACTOSE;L-Galactose, 6-deoxy-;L-fucopyranose;(2S,3R,4R,5S)-2,3,4,5-tetrahydroxyhexanal;L-(-)-Fucose ,99%;6-DEOXY-BETA-GALACTOSE;Fuose;L-FUCOSE;L-FUCOSE
- CBNumber:
- CB1448036
- Molecular Formula:
- C6H12O5
- Molecular Weight:
- 164.16
- MOL File:
- 2438-80-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/17 9:16:14
| Melting point | 150-153 °C(lit.) |
|---|---|
| Boiling point | 211.61°C (rough estimate) |
| alpha | -73～-77°(D/20℃)(c=4,H2O,24hr) |
| Density | 1.1738 (rough estimate) |
| refractive index | -75.5 ° (C=10, H2O) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O: 0.1 g/mL, clear, colorless |
| pka | 12.50±0.20(Predicted) |
| form | Powder |
| color | Beige to light brown to purple-grayish |
| Water Solubility | Soluble in water. |
| Sensitive | Hygroscopic |
| Merck | 14,4279 |
| BRN | 1723321 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | SHZGCJCMOBCMKK-DLABPRKASA-N |
| LogP | -0.340 (est) |
| CAS DataBase Reference | 2438-80-4(CAS DataBase Reference) |
| EPA Substance Registry System | L-Galactose, 6-deoxy- (2438-80-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29400090 | |||||||||
| NFPA 704 |
|
L-Fucose price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F2252 | L-(−)-Fucose ≥99% | 2438-80-4 | 10MG | ₹3431.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F2252 | L-(−)-Fucose ≥99% | 2438-80-4 | 5G | ₹14202.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F2252 | L-(−)-Fucose ≥99% | 2438-80-4 | 25G | ₹56755.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F2252 | L-(−)-Fucose ≥99% | 2438-80-4 | 100G | ₹195304.65 | 2022-06-14 | Buy |
| TCI Chemicals (India) | F0065 | L-(-)-Fucose | 2438-80-4 | 1G | ₹2800 | 2022-05-26 | Buy |
L-Fucose Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.
Chemical Properties
l-fucose is a six-carbon sugar also known as 6-deoxy-l-galactose. Its molecular formula is C6H12O5 and its melting point is 150.0–153.0 °C. It is a white crystalline powder that easily absorbs moisture, and its hydrophilicity is weaker than that of other monosaccharides. l-fucose is the main form of fucose found in nature and is also the only levorotatory sugar used by mammals, while d-fucose is found only in some glycosides[1].
Occurrence
L-Fucose exists in nature in various biological niches. A major natural source of L-fucose is the brown algal polysaccharide fucoidan. It is also present in the polysaccharides of tragacanth, potatoes, kiwi, soybeans, varieties of wing peas, canola and other plants.L-Fucose is a minor component in plant cell wall polysaccharides, specifically rhamnogalacturonan, xyloglucan and also arabinogalactan proteins that are involved in plant cell elongation.
Uses
L-Fucose was isolated from seaweed. It finds application in cosmetics, pharmaceuticals and dietary supplements. It is used in the determination of antigen in A and B blood group. It is also used in the selection-mediated leukocyte-endothelial adhesion and host-microbe interactions. L-Fucose is also used in anti aging creams as well as to promote the accelerated healing of wounds and to reduce allergy.
Definition
ChEBI: L-fucopyranose is the pyranose form of L-fucose. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a L-fucose and a fucopyranose.
Reactions
L-Fucose is oxidised by the enzyme L-fucose dehydrogenase in the presence of nicotinamide-adenine dinucleotide phosphate (NADP+) to L-fucono-1,5-lactone with the formation of reduced nicotinamideadenine dinucleotide phosphate (NADPH) (1).
(L-fucose dehydrogenase) (1)
L-Fucose + NADP+ --> L-fucono-1,5-lactone + NADPH + H+
The amount of NADPH formed in this reaction is stoichiometric with the amount of L-fucose. It is the NADPH which is measured by the increase in absorbance at 340 nm.
Biological Functions
l-fucose has many biological functions like the antitumor effect and relieving intestinal disease, and exhibits potential as an emulsifier in the food industry. It can be used as a functional food and one of the components of bacteriostatic agents. Moreover, it also has an anti-aging function[1].
Biological Activity
L-Fucose (6-Deoxy-L-galactose) is used in studies of fucoidan polysaccharides containing glycans. It is studied as a glycan modifying carbohydrate that generates antigenic sites recognized by IgE antibodies. It is used as a substrate to identify, differentiate, and characterize enzymes such as fucosidase(s),l-fucose isomerase(s), and L-fucose dehydrogenase(s). It may be used to study organelles, and bacterial microcompartments, involved in the degradation of plant and algal cell wall sugars. L-Fucose may also be used as a reference compound in rare sugar identification and analysis.
References
[1] Yan Wang . “Research progress on the functions, preparation and detection methods of l-fucose.” Food Chemistry 433 (2023): Article 137393.
L-Fucose Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Merck Life Science Private Limited | 08046045443 | Mumbai, India | 101 | 58 | Inquiry |
| Souvenier Chemicals | 08048372762Ext 645 | Mumbai, India | 396 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
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