3-Fluoro-4-methylphenol
- CAS No.
- 452-78-8
- Chemical Name:
- 3-Fluoro-4-methylphenol
- Synonyms
- 3-FLUORO-P-CRESOL;3-Fluoro-p-cresol>3-FLUORO-4-METHYLPHENOL;3-Fluoro-p-cresol (OH=1);2-Fluoro-4-hydroxytoluene;Phenol, 3-fluoro-4-methyl-;3-Fluoro-4-methylphenol, JRD,
- CBNumber:
- CB1478242
- Molecular Formula:
- C7H7FO
- Molecular Weight:
- 126.13
- MOL File:
- 452-78-8.mol
- Modify Date:
- 2024/8/5 20:55:42
| Melting point | 72 °C |
|---|---|
| Boiling point | 196 °C |
| Density | 1.17 |
| refractive index | 1.5150 |
| Flash point | 29 °C |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to lump |
| pka | 9.27±0.18(Predicted) |
| color | White to Light yellow to Light orange |
| Odor | Phenol-like |
| InChI | InChI=1S/C7H7FO/c1-5-2-3-6(9)4-7(5)8/h2-4,9H,1H3 |
| InChIKey | GJOOCAXPERKNMN-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(C)C(F)=C1 |
| CAS DataBase Reference | 452-78-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H227-H302-H312-H314-H318 | |||||||||
| Precautionary statements | P305+P351+P338-P309-P310-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 21/22-34-52-36-22 | |||||||||
| Safety Statements | 26-36/37/39-60-45 | |||||||||
| RIDADR | 2922 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 29081990 | |||||||||
| NFPA 704 |
|
3-Fluoro-4-methylphenol price More Price(2)
3-Fluoro-4-methylphenol Chemical Properties,Uses,Production
Uses
3-Fluoro-4-methylphenol is a phenolic derivative and can be used as a pharmaceutical intermediate.
Synthesis
3-Fluoro-4-methylaniline (5g, 39.95Immol) was dissolved in 10% sulfuric acid aqueous solution (100ml). Thereafter, the temperature was lowered to 0°C. thereto sodium nitrate (5.5g, 79.902mmol) was added, and the reaction mixture was stirred at same temperature for 30 minutes. Then the reaction mixture was stirred at 50°C for 30 minutes, and the last time, stirred at 80°C for 5 hours. Ice water was added to quench the reaction, and aqueous layer was extracted with ethyl acetate. Combined organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (n-hexane:ethyl acetate = 8:1) to give 2.26g (yield: 44.8%, colorless oil) of the target compound. 3-fluoro-4-methylphenol, yield 2.26g, 44.8% 1H NMR(400MHz, CDCl3): 6.98(1, J=8.6Hz, 1H), 6.52(m, 2H), 5.82(br, 1H), 2.12(s, 3H).
3-Fluoro-4-methylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | China | 2673 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | China | 1080 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | CHINA | 21149 | 58 | Inquiry |
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