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Ryanodine

CAS No.: 15662-33-6

Chemical Name:: Ryanodine

Synonyms: Ryanex;ryania;RYANADOL;ryanexel;Ryanexcel;Ryanicide;RYANODINE;bonideryatox;ryaniapowder;Ryanodine,99%

CBNumber:: CB1480087

Molecular Formula:: C25H35NO9

Molecular Weight:: 493.55

MOL File:: 15662-33-6.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

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Ryanodine Properties

alpha	D25 +26° (methanol)
Boiling point	586.95°C (rough estimate)
Density	1.2805 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO: soluble10mg/mL, clear
form	White solid
Melting point	219-220 °C
pka	10.66±0.70(Predicted)
color	white to beige
CAS DataBase Reference	15662-33-6
EPA Substance Registry System	Ryanodine (15662-33-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H302+H312-H410
Precautionary statements	P264-P270-P273-P280-P301+P312-P302+P352+P312
Hazard Codes	Xn,N
Risk Statements	21/22-50/53
Safety Statements	36/37-60-61
RIDADR	UN 3077 9/PG 3
RTECS	VM4025000

Ryanodine price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	559276	Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem Naturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum.	15662-33-6	500μG	₹20000	2022-06-14	Buy
Sigma-Aldrich(India)	559276	Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem Naturally occurring alkaloid that blocks the release of Ca2+ from the sarcoplasmic reticulum.	15662-33-6	500μG	₹20000	2022-06-14	Buy

Product number	Packaging	Price	Buy
559276	500μG	₹20000	Buy
559276	500μG	₹20000	Buy

Ryanodine Chemical Properties,Uses,Production

Description

Ryania insecticide is the ground stem wood of the tropical tree Ryania speciosa Vahl., and it contains over a dozen of several structurally related alkaloids. Nowadays, this botanical preparation is of minor importance, but one of its major ingredients, ryanodine, is a widely used pharmacological tool in studies of the calcium release channels in sarcoplasmic reticulum membranes of skeletal and cardiac muscle of both insects and mammals (11,12).

Chemical Properties

white to off-white solid

Uses

Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum with potential application towards the treatment of huntingtons disease.

Definition

ChEBI: An insecticide alkaloid isolated from South American plant Ryania speciosa.

Biological Activity

Potent inhibitor of Ca 2+ release from sarcoplasmic reticulum (IC 50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

References

Rogers et ai., J. Amer. Chem. Soc., 70, 3086 (1948)
Kelly, Whittingham, Wusner., Chem. Ind., 857 (1952)
Structure:
Wiesner, Valenta, Findlay., Tetrahedron Lett., 221 (1967)
Hollstein, Rapoport.,J. Amer. Chem. Soc., 90,3864 (1968)
Wong, Hollstein, Rapoport., ibid, 90, 3866 (1968)
Wiesner., Collect. Czech. Chem. Commun., 33, 2656 (1968)
Crystal structure:
Srivastava, Przybylska., Can. J. Chem., 46,795 (1968)

Ryanodine Preparation Products And Raw materials

Raw materials

Preparation Products

Ryanodine Suppliers

Global( 115)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30253	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd.	+86-18521732826	China	48467	58	Inquiry
SHANGHAI ZZBIO CO., LTD.	19921389125 19921389125	China	12065	58	Inquiry
Hubei CuiRan Biotechnology Co., Ltd.	181-86211184 18162791556	China	4351	58	Inquiry
MedChemExpress	021-58955995	United States	6398	58	Inquiry
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	China	29778	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Aladdin Scientific	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	58
SHANGHAI ZZBIO CO., LTD.	58
Hubei CuiRan Biotechnology Co., Ltd.	58
MedChemExpress	58
Beijing Jin Ming Biotechnology Co., Ltd.	58

15662-33-6(Ryanodine)Related Search:

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Ryanex Ryanexcel Ryanodine,99% 6-(1α,5aβ,8aβ,9-pentahydroxy-7β-isopropyl-2β,5β,8β-trimethylperhydro-8bα,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate ryania Ryanodine from Ryania speciosa Ryanodol 3-(1H-pyrrole-2-carboxylate) from Ryania speciosa RYANODINE MIXTURE RYANADOL RYANADOL 3-(1H-PYRROLE-2-CARBOXYLATE) Ryania(content>30%) Ryanicide RYANODINE RYANODOL-3-(1H-PYRROLE-2-CARBOXYLATE) 1H-PYRROLE-2-CARBOXYLIC ACID, (3S,4R,4AR,6S,7S,8R,8AS,8BR,9S,9AS)-DODECAHYDRO-4,6,7,8A,8B,9A-HEXAHYDROXY-3,6A,9-TRIMETHYL-7-(1-METHYLETHYL)-6,9-METHANOBENZO[1,2]PENTALENO[1,6-BC]FURAN-8-YL ESTER 3-(1H-PYR-ROLE-2-CARBOXYLATE) bonideryatox groundryaniaspecisa(vahl)stemwood(alkoloidryanodine) ryanexel ryania ryaniapowder ryaniaspeciosa ryanodinealkaloid 6-(1alpha,5abeta,8abeta,9-pentahydroxy-7beta-isopropyl-2beta,5beta,8beta-trimethylperhydro-8balpha,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl) pyrrole-2-carboxylate RYANODINE >98% (RYANADOL, 3-(1H-PYRR RYANODINE FROM RYANIA SPECIOSA MINIMUM & RYANODINE FROM RYANIA SPECIOSA INHIBITS CALCIUM RELEASE FROM THE SARCOPLASMIC RETICULUM RYANODINE FROM RYANIA SPECIOSA A MIXTURE OF RYANODINE AND 9,21-DEHYDRORYANODINE (1:1) RYANODINE HIGH PURITY 1H-Pyrrole-2-carboxylicacid(3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethy] 9,21-DEHYDRO(RG) Ryanodine, High Purity - CAS 15662-33-6 - Calbiochem 1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester 15662-33-6 C25H35NO9 Signalling Alkaloids InsP3/Ryanodine receptor