Bilobalide
- CAS No.
- 33570-04-6
- Chemical Name:
- Bilobalide
- Synonyms
- BILOBALID;BILOBALIDE;VITEXICARPIM;Bilobalide A;Ginkgolactone;BILOBALIDE(SH);(-)-BILOBALIDE;Bilobalide >BILOBALIDE(AHP);Bilobalide USP/EP/BP
- CBNumber:
- CB1688713
- Molecular Formula:
- C15H18O8
- Molecular Weight:
- 326.3
- MOL File:
- 33570-04-6.mol
- Modify Date:
- 2024/7/2 8:55:01
| Melting point | >300° |
|---|---|
| alpha | 57820 -64.3° (c = 2 in acetone) |
| Boiling point | 651.7±55.0 °C(Predicted) |
| Density | 1.56±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Acetone (Slightly), Methanol (Slightly) |
| pka | 11.74±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| Merck | 14,1220 |
| Stability | Hygroscopic |
| LogP | -0.450 (est) |
| CAS DataBase Reference | 33570-04-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H317-H318-H410 |
| Precautionary statements | P261-P264-P270-P272-P273-P280-P301+P312+P330-P302+P352-P305+P351+P338+P310-P333+P313-P391-P501 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | LV1665000 |
| F | 10 |
| HS Code | 29322090 |
Bilobalide price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B9031 | (−)-Bilobalide from Ginkgo biloba leaves ≥93% (HPLC) | 33570-04-6 | 10MG | ₹15079.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B9031 | (−)-Bilobalide from Ginkgo biloba leaves ≥93% (HPLC) | 33570-04-6 | 25MG | ₹22083 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B9031 | (−)-Bilobalide from Ginkgo biloba leaves ≥93% (HPLC) | 33570-04-6 | 100MG | ₹72971.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 79593 | (−)-Bilobalide analytical standard | 33570-04-6 | 10MG | ₹29205.85 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B4388 | Bilobalide min. 96.0 % | 33570-04-6 | 10MG | ₹9000 | 2022-05-26 | Buy |
Bilobalide Chemical Properties,Uses,Production
Description
Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. It has been shown to protect against cerebral edema, decrease cortical infarct volume, and reduce cerebral ischemic damage. Bilobalide, at 10 μM, reduces the release of glycine and glutamate from hippocampal slices under ischemic conditions. It also activates the rat constitutive androstane receptor at 100 μM and increases the levels and activities of several cytochrome P450 isoforms in rat liver microsomes.
Uses
Reference Standard in the analysis of herbal medicinal products
Definition
ChEBI: A terpenoid trilactone found in extracts of Ginkgo biloba.
General Description
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
Enzyme inhibitor
This plant natural product (FW = 326.30 g/mol; CAS 33570-04-6) from the gingko tree (Ginkgo biloba) is a terpene trilactone that exhibits anticonvulsant properties. Bilobalide has multiple mechanisms of action (e.g., acting as a GABAA receptor antagonist (/1), preserving mitochondrial ATP synthesis, inhibiting staurosporine-induced apoptotic damage, suppressing hypoxia-induced membrane deterioration in the brain, and increasing the expression the mitochondrial DNA-encoded COX III subunit of cytochrome c oxidase and the ND1 subunit of NADH dehydrogenase). Bilobalide was later synthesized in E. J. Corey’s laboratory in the late 1980s.
Bilobalide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | China | 1250 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 2989 | 58 | Inquiry |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | China | 1000 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3424 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 3000 | 58 | Inquiry |