FUMONISIN B1
![FUMONISIN B1 Structure](CAS/GIF/116355-83-0.gif)
- CAS No.
- 116355-83-0
- Chemical Name:
- FUMONISIN B1
- Synonyms
- FB1;MACROFUSINE;FUMONISIN B1;B1 Fumonisin B1;Fumonisin B1,96%;FUMONISIN B1 98%;Fumonisin B1 ,95%;Fumonisin B1 (FB1);fumonisin b1solution;FuMonisin B1, 96% 1MG
- CBNumber:
- CB1773259
- Molecular Formula:
- C34H59NO15
- Molecular Weight:
- 721.83
- MOL File:
- 116355-83-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
Melting point | >60oC |
---|---|
Boiling point | 713.81°C (rough estimate) |
Density | 1.2207 (rough estimate) |
refractive index | 1.6630 (estimate) |
Flash point | 6 °C |
storage temp. | 2-8°C |
solubility | Soluble in Water (up to 25 mg/ml). |
form | Powder |
pka | 3?+-.0.23(Predicted) |
color | White to tan |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
CAS DataBase Reference | 116355-83-0 |
IARC | 2B (Vol. 56) 1993, 2B (Vol. 82) 2002 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS06,GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H301-H351-H361d-H373 |
Precautionary statements | P201-P301+P310+P330 |
Hazard Codes | Xn,T,F |
Risk Statements | 40-36-20/21/22-11 |
Safety Statements | 36/37-16-26-45 |
RIDADR | 3172 |
WGK Germany | 3 |
RTECS | TZ8350000 |
HazardClass | 6.1(b) |
PackingGroup | III |
HS Code | 29221990 |
FUMONISIN B1 price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | F1147 | Fumonisin B1 from Fusarium moniliforme ≥98% (HPLC) | 116355-83-0 | 1MG | ₹15284.9 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML1286 | Fumonisin B1 Ready Made Solution (Fusarium moniliforme), 1?mg/mL in DMSO | 116355-83-0 | 1ML | ₹17236.8 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | F1147 | Fumonisin B1 from Fusarium moniliforme ≥98% (HPLC) | 116355-83-0 | 5MG | ₹60176.18 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | F1147 | Fumonisin B1 from Fusarium moniliforme ≥98% (HPLC) | 116355-83-0 | 10MG | ₹98085.33 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 34139 | Fumonisin B1 solution ~50?μg/mL in acetonitrile: water, analytical standard | 116355-83-0 | 1ML | ₹30776.2 | 2022-06-14 | Buy |
FUMONISIN B1 Chemical Properties,Uses,Production
Chemical Properties
white to tan powder
Uses
Fumonisin B1 is a major analogue of a family of potent mycotoxins produced by various Fusarium species, associated with animal toxicity worldwide. In vitro, fumonisin B1 inhibits sphingosine N-acyl-transferase (ceramide synthase) and blocks the growth of axons.
General Description
Fumonisin B1 is a neurotoxin and a phytotoxin. A cell-permeable mycotoxin that inhibits sphingolipid biosynthesis in rat kidney and in liver microsomes by inhibition of sphingosine N-acyltransferase (ceramide synthase) (IC50 = 100 nM). Cellular effects also appear to be induced by micromolar levels of FB1. Because it inhibits ceramide synthase activity, it elevates cellular levels of sphingoid bases, including sphinganine, resulting in overall inhibition of sphingolipid biosynthesis. Preferentially inhibits sphingomyelin biosynthesis in neuronal cells. Has carcinogenic properties.
Biological Activity
Mycotoxin produced by Fusarium moniliforme . Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC 50 ~ 75 nM). Also inhibits protein phosphatases; IC 50 values are 80, 300, 400, 500 and 3000 μ M for PP5, PP2C α , PP2A, PP1 γ 2 and PP2B respectively.
FUMONISIN B1 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
LGC Standards | +44 (0)20 8943 8480 | United Kingdom | 6495 | 0 | Inquiry |
Supplier | Advantage |
---|---|
Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
Pharma Affiliates | 58 |
CLEARSYNTH LABS LTD. | 58 |
ATK CHEMICAL COMPANY LIMITED | 60 |
TargetMol Chemicals Inc. | 58 |
Hubei Ipure Biology Co., Ltd | 58 |
BOC Sciences | 58 |
LEAPCHEM CO., LTD. | 58 |
Aladdin Scientific | 58 |
LGC Standards | 0 |