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4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE

4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE Structure
CAS No.
301836-43-1
Chemical Name:
4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE
Synonyms
D4476;D4467;CS-1031;D4476 (D-4476);D4476;D 4476;D-4476;Casein Kinase I Inhibitor;Casein Kinase I Inhibitor, D4476;CASEIN KINASE I INHIBITOR; D 4476; D-4476;Casein Kinase I Inhibitor, D4476 - CAS 301836-43-1 - Calbiochem;Casein Kinase,inhibit,Autophagy,D-4476,D4476,Inhibitor,Apoptosis
CBNumber:
CB1811579
Molecular Formula:
C23H18N4O3
Molecular Weight:
398.41
MOL File:
301836-43-1.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE Properties

Boiling point 675.0±55.0 °C(Predicted)
Density 1.338±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ~20mg/mL
pka 10.16±0.10(Predicted)
form solid
color light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
WGK Germany  3

4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) D1944 D4476 ≥98% (HPLC), solid 301836-43-1 1MG ₹24540.28 2022-06-14 Buy
Sigma-Aldrich(India) D1944 D4476 ≥98% (HPLC), solid 301836-43-1 5MG ₹78741.05 2022-06-14 Buy
Sigma-Aldrich(India) 218696 Casein Kinase I Inhibitor, D4476 - CAS 301836-43-1 - Calbiochem The Casein Kinase I Inhibitor, D4476, also referenced under CAS 301836-43-1, controls the biological activity of Casein Kinase I. This small molecule/ 301836-43-1 1MG ₹21460 2022-06-14 Buy
Product number Packaging Price Buy
D1944 1MG ₹24540.28 Buy
D1944 5MG ₹78741.05 Buy
218696 1MG ₹21460 Buy

4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE Chemical Properties,Uses,Production

Description

D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1; IC50 = 200 nM from S. pombe, 300 nM for CK1δ). It is a less effective inhibitor of PKD1 (IC50 = 9.1 μM) and p38α MAPK (IC50 = 5.8 μM), and only weakly affects the activities of a panel of kinases tested. D 4476 blocks CK1-mediated phosphorylation of FOXO1a, RhoB, and p53. As an inhibitor of ALK5, D 4476 prevents Smad3 activation and suppresses TGF-β1-induced gene expression without cytotoxicity in A498 cells.

Uses

4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide is a novel CK1 inhibitor that potently inhibits CK1 with an IC50 value of 78 nM.

Biological Activity

Selective inhibitor of casein kinase 1 (CK1) and TGF- β type-I receptor (ALK5) that displays > 20-fold selectivity over SAPK2/p38 and a much greater selectivity over all other protein kinases tested. Suppresses site-specific phosphorylation and nuclear exclusion of FOXO1a.

4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE Suppliers

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CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
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TargetMol Chemicals Inc. 58
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InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Henan Fengda Chemical Co., Ltd 58

4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE Spectrum

4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE(301836-43-1)1HNMR

301836-43-1(4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE)Related Search:

Isochroman Phthalan Dibenzothiophene 2-(1H-IMIDAZOL-4-YL)-PYRIDINE 4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE
2-(3H-Imidazol-4-yl)-pyridine 4-(1H-IMIDAZOL-2-YL)-BENZYLAMINE 4-(1H-IMIDAZOL-2-YL)-BENZAMIDE 4-(4-METHOXYPHENYL)-2-PHENYL-1H-IMIDAZO&
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4-(4-(2,3-DIHYDROBENZO[1,4]DIOXIN-6-YL)-5-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE D4476 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide Casein Kinase I Inhibitor 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide D4476 Casein Kinase I Inhibitor, D4476 D4476;D 4476;D-4476 Benzamide,4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]- 4-(4-(2,3-DIHYDROBENZO[B][1,4]DIOXIN-6-YL)-5-(PYRIDIN-2-YL)-1H-IMIDAZOL-2-YL)BENZAMIDE D4467 Casein Kinase I Inhibitor, D4476 - CAS 301836-43-1 - Calbiochem CS-1031 D4476 (D-4476) CASEIN KINASE I INHIBITOR; D 4476; D-4476 Casein Kinase,inhibit,Autophagy,D-4476,D4476,Inhibitor,Apoptosis 301836-43-1 Inhibitors Signalling