2-(4-isobutylphenyl)propionaldehyde

CAS No.: 51407-46-6

Chemical Name:: 2-(4-isobutylphenyl)propionaldehyde

Synonyms: Ibuprofen Aldehyde;Ibuprofen Impurity 75;2-(4-Isobutylphenyl)propanal;2-(4-isobutylphenyl)propionaldehyde;p-(2-Methylpropyl)hydratropaldehyde;2-[4-(2-Methylpropyl)phenyl]propanal;α-Methyl-4-isobutylbenzeneacetaldehyde;(2RS)-2-[4-(2-Methylpropyl)phenyl]propan-1-al;A-METHYL-4-(2-METHYLPROPYL)BENZENEACETALDEHYDE;α-Methyl-4-(2-methylpropyl)benzeneacetaldehyde

CBNumber:: CB1902754

Molecular Formula:: C13H18O

Molecular Weight:: 190.28

MOL File:: 51407-46-6.mol

MSDS File:: SDS

Modify Date:: 2023/10/21 13:33:47

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2-(4-isobutylphenyl)propionaldehyde Properties

Boiling point	64-65 °C(Press: 0.2 Torr)
Density	0.937±0.06 g/cm3(Predicted)
storage temp.	Hygroscopic, Refrigerator, under inert atmosphere
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Oil
color	Colourless
Stability	Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H319-H315
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501

2-(4-isobutylphenyl)propionaldehyde Chemical Properties,Uses,Production

Uses

2-(4-Isobutylphenyl)propanal is an impurity of the drug Ibuprofen (I140000), a selective cyclooxygenase inhibitor that also inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.

Production Methods

Numerous methods are known for the synthesis of 2-(4-isobutylphenyl)propionaldehyde. It can be prepared by reaction of p-isobutylacetophenone with methyl chloroacetate using sodium methoxide as catalyst, followed by reaction of the glycidic ester with BF3 to give 2- hydroxy-3-(4-isobutylphenyl)-3-butenoic acid methyl ester, which is subsequently treated with mineral acid Avariant of the process is the hydrolysis of the intermediately formed glycidic ester with alkali to give the corresponding salt of glycidic acid, which is then decarboxylated. In addition, 2-(4-isobutylphenyl)propanal is formed by isomerization of 2-(4-isobutylphenyl)- 2-methyloxirane on Al2O3-SiO2 or anhydrous ZnCl2, by reaction of 1-(4-isobutylphenyl)- 1-chloroethane with dimethylformamide in the presence of Li or Na in tetrahydrofuran, and in good yields by Rh- or Co-catalyzed hydroformylation of p-isobutylstyrene.
2-(4-isobutylphenyl)propionaldehyde

2-(4-isobutylphenyl)propionaldehyde Preparation Products And Raw materials

Raw materials

Ethyl butyrate Aluminum chloride Sodium Butyrate Sodium propan-2-olate Ethyl chloroacetate

Preparation Products

2-(4-isobutylphenyl)propionaldehyde oxime

2-(4-isobutylphenyl)propionaldehyde Suppliers

Global( 38)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6739	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6754	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6514	58	Inquiry
Chemicea Pharmaceuticals Pvt Ltd	+91-9881765045/+91-8796656135	Pune, India	825	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	China	4086	58	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15354	58	Inquiry
China National Standard Pharmaceutical Corporation Limited	+8615391658522	China	11922	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43340	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131957	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
SynZeal Research Pvt Ltd	58
Chemicea Pharmaceuticals Pvt Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
AFINE CHEMICALS LIMITED	58
China National Standard Pharmaceutical Corporation Limited	58
LEAPCHEM CO., LTD.	58
Amadis Chemical Company Limited	58

51407-46-6(2-(4-isobutylphenyl)propionaldehyde)Related Search:

1-Hydroxyibuprofen Ibuprofen Isopropyl Ester 1-Oxo Ibuprofen Ibuprofen Ethyl Ester 1,3-bis(4-isobutylphenyl)butan-1-one

2-(4-Methylphenyl)propanoic acid Ibuprofen Ester Impurity Ibuprofen Impurity 4 4'-(2-Methylpropyl)acetophenone 4-(2-Methylpropyl)benzeneethanol

4-Benzyloxybenzaldehyde Ibuprofen EP Impurity I 3-(4-ISOBUTYL-PHENYL)-PROPIONIC ACID Ibuprofen Impurity 2 CARBOXYIBUPROFEN

p-Isobutylstyrene rac a-Hydroxy Ibuprofen Ibuprofen Impurity 10

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A-METHYL-4-(2-METHYLPROPYL)BENZENEACETALDEHYDE 2-(4-Isobutylphenyl)propanal 2-[4-(2-Methylpropyl)phenyl]propanal p-(2-Methylpropyl)hydratropaldehyde α-Methyl-4-isobutylbenzeneacetaldehyde alpha-Methyl-4-(2-Methylpropyl)benzeneacetaldehyde 2-(4-isobutylphenyl)propionaldehyde α-Methyl-4-(2-methylpropyl)benzeneacetaldehyde Ibuprofen Aldehyde Benzeneacetaldehyde, α-methyl-4-(2-methylpropyl)- Ibuprofen Impurity 75 (2RS)-2-[4-(2-Methylpropyl)phenyl]propan-1-al 51407-46-6