Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound > 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Structure
CAS No.
143782-23-4
Chemical Name:
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile
Synonyms
4-isothiocyanato-2-(trifluoroMethyl)benzonitrile;D3-EZ-S2;4-Isothiocyanato-2;Enzalutamide Impurity Z;Enzalutamide Impurity 21;Enzalutamide Impurity N7;Enzalutamide intermediate;-Fluoro-4-methylphenylisothiocyanate;4-isothiocyano-2 -(trixenon methyl) benzol;4-cyano-3-trifluoromenthylphenylisothiocyanate
CBNumber:
CB21107300
Molecular Formula:
C9H3F3N2S
Molecular Weight:
228.19
MOL File:
143782-23-4.mol
MSDS File:
SDS
Modify Date:
2024/8/30 16:37:05
Request For Quotation

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Properties

Melting point 39.0 to 43.0 °C
Boiling point 331℃
Density 1.31
Flash point 154℃
storage temp. Inert atmosphere, 2-8°C
solubility Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly)
form powder to lump
color White to Yellow to Green
Stability Hygroscopic, Moisture sensitive
InChI InChI=1S/C9H3F3N2S/c10-9(11,12)8-3-7(14-5-15)2-1-6(8)4-13/h1-3H
InChIKey TYXKOMAQTWRDCR-UHFFFAOYSA-N
SMILES C(#N)C1=CC=C(N=C=S)C=C1C(F)(F)F
CAS DataBase Reference 143782-23-4

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H227
Precautionary statements  P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235
HS Code  2929100090
NFPA 704
0
2 0

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) I0987 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile min. 98.0 % 143782-23-4 1G ₹4700 2022-05-26 Buy
TCI Chemicals (India) I0987 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile min. 98.0 % 143782-23-4 5G ₹16300 2022-05-26 Buy
Product number Packaging Price Buy
I0987 1G ₹4700 Buy
I0987 5G ₹16300 Buy

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Chemical Properties,Uses,Production

Uses

4-Isothiocyanoyl-2-(trifluoromethyl)benzonitrile is a reagent used to synthesize thioimidazolinone compounds and is a potential anti-prostate cancer drug. It is also used as an intermediate of enzalutamide.

Synthesis

Synthesis_143782-23-4
4-Amino-2-trifluoromethylbenzonitrile, (2.23 g, 12 mmol) was added portionwise over15 minutes into the well-stirred heterogeneous mixture of thiophosgene (1 ml, 13 mmol) in water (22 ml) at room temperature. Stirring was continued for an additional 1 h. The reaction medium was extracted with chloroform (3 x 15 ml). The combined organic phase was dried over MgSO4 and evaporated to dryness under reduced pressure to yield desired product, 4-isothiocyanato-2-trifluoromethylbenzonitrile, (Ia), as brownish solid and was used as such for the next step (2.72 g, 11.9 mmol, 99%).

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

4-(3-(4-hydroxyphenyl)-4,4-diMethyl-5-oxo-2-thioxoiMidazolidin-1-yl)-2-(trifluoroMethyl)benzonitrile Enzalutamide

4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Suppliers

Global( 432)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
GLR Innovations +91 9891111994 New Delhi, India 4542 58 Inquiry
Molkem Chemicals +91-917228022464 +91-7228022464 Ahmedabad, India 138 58 Inquiry
Shree Jaya Laboratories Pvt. Ltd. +91-91-40-29881167 +91-9966167167 Hyderabad, India 78 58 Inquiry
VGS SYNTHESIS PRIVATE LIMITED +91-9866975588 +91-9866975588 Hyderabad, India 1818 58 Inquiry
Greenovel life sciences Pvt Ltd Hyderabad, India 138 58 Inquiry
Sekhment pharmaventures +91-9030088669 +91-9030088669 Mumbai, India 105 58 Inquiry
Radison Labs Private Limited +91-7337551966 +91-7337551966 Hyderabad, India 58 58 Inquiry
Briti Scientific +91-8790384772 +91-8179784772 Telangana, India 54 58 Inquiry
Optimus Pharma Pvt Ltd (Sekhmet Pharmaventures)) +91-9100091731 +91-9573334999 Telangana, India 57 58 Inquiry
Mekong pharmaceuticals pvt ltd +91-4035163894 +91-8008212221 Telangana, India 129 58 Inquiry
Supplier Advantage
GLR Innovations 58
Molkem Chemicals 58
Shree Jaya Laboratories Pvt. Ltd. 58
VGS SYNTHESIS PRIVATE LIMITED 58
Greenovel life sciences Pvt Ltd 58
Sekhment pharmaventures 58
Radison Labs Private Limited 58
Briti Scientific 58
Optimus Pharma Pvt Ltd (Sekhmet Pharmaventures)) 58
Mekong pharmaceuticals pvt ltd 58

143782-23-4( 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile)Related Search:

2,2-Dimethyl-1,3-propanediol FLUCYTHRINATE Cyfluthrin 2,4-DICHLOROPHENYL CHLOROTHIOFORMATE 3,5-DIMETHYLPHENYL CHLOROTHIOFORMATE
PENTAFLUOROPHENYL CHLOROTHIONOFORMATE Phenyl chlorothionocarbonate CHLOROCARBONYLSULFENYL CHLORIDE 1,4-PHENYLENE DIISOTHIOCYANATE o-5,6,7,8-Tetrahydro-2-naphtylthiochloroformate
2-BROMO-4-FLUOROPHENYL CHLOROTHIOFORMATE 4-(trifluoromethoxy)phenyl chlorothioformate methyl 4-(chlorocarbonothioyloxy)benzoate 4-CHLOROPHENYL CHLOROTHIONOFORMATE 4-amino-2-fluoro-N-methylbenzamide
4-Bromo-2-fluoro-N-methylbenzamide 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- Enzalutamide Impurity 7
chevron_left

1of4

chevron_right
Benzonitrile,4-isothiocyanato-2-(trifluoroMethyl)- 3. 4-Isothiocyanato-2-(trifluoroMethyl)benzonitrile 4-cyano-3-trifluoromenthylphenylisothiocyanate 4-Isothiocyanato-2-(trifluoromethyl)benzonitrile,Enzalutamide intermediate 4-isothiocyananto-2-(trifluoromethyl) benzonitrile 4-ISOTHIOCYANATO-2-(TRIFLUOROMETHYL)BENZONITRILE/4-CYANO-3-TRIFLUOROMETHYLPHENYLISOTHIOCYANATE /CAS NO: 143782-23-4 Enzalutamide intermediate Enzalutamide Impurity Z Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzeneQ: What is Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene Q: What is the CAS Number of Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene Q: What is the storage condition of Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene Q: What are the applications of Benzonitrile 4-Isothiocyanato-2-trifluoromethyl-2-fluoro-4-isothiocyanato1-methylbenzene 4-Isothiocyanato-2 Isothiocyanato-2-(trifluoromethyl)benzonitrile 4-ISOTHIOCYANATO-2-(TRIFLUOROMETHYL)BENZONITRILE (CAS : 143782-23-4) (intermediate of Enzalutamide) 4-isothiocyanoyl-2 - (trifluoromethyl) benzonitrile Enzalutamide Impurity 21 Isothiocyanic Acid 4-Cyano-3-(trifluoromethyl)phenyl Ester 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile 4-isothiocyano-2 - (trifluoromethyl) benzonitrile 4-isothiolamino-2-(trifluoromethyl)benzene Melonitrile -Fluoro-4-methylphenylisothiocyanate 4-Cyano-3-(trifluoromethyl)phenylIsothiocyanate,98% 4-isothiocyano-2 -(trixenon methyl) benzol Enzalutamide Impurity N7 4-cyano-3-trifluoromenthylphenylisothiocyaChemicalbooknate 4-Isothiocvanato-2-(trifluoromethyl)benzonitrile D3-EZ-S2 143782-23-4 123782-23-4 143782-23-4