Honokiol
- CAS No.
- 35354-74-6
- Chemical Name:
- Honokiol
- Synonyms
- Magnolia officinalis extract;Piclidenoson;Magnolia officinalis oil;hnk;Honokiol D10;1’-Biphenyl]-2,4’-diol,3’,5-di-2-propenyl-[1;houpa;HONOKIOL;NSC 293100;Honokiol>
- CBNumber:
- CB2111629
- Molecular Formula:
- C18H18O2
- Molecular Weight:
- 266.33
- MOL File:
- 35354-74-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 86℃ |
|---|---|
| Boiling point | 400.1±40.0 °C(Predicted) |
| Density | 1.107±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 36 mg/mL |
| form | powder |
| pka | 9.89±0.48(Predicted) |
| color | White to Off-White |
| Merck | 14,4742 |
| Stability | Light Sensitive |
| InChIKey | FVYXIJYOAGAUQK-UHFFFAOYSA-N |
| LogP | 4.200 (est) |
| CAS DataBase Reference | 35354-74-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318-H411 | |||||||||
| Precautionary statements | P273-P280-P305+P351+P338-P391-P501 | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 41-51/53 | |||||||||
| Safety Statements | 26-39-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 9 | |||||||||
| HS Code | 29072990 | |||||||||
| NFPA 704 |
|
Honokiol price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H4914 | Honokiol ≥98% (HPLC), powder | 35354-74-6 | 10MG | ₹15523.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H4914 | Honokiol ≥98% (HPLC), powder | 35354-74-6 | 25MG | ₹31035.28 | 2022-06-14 | Buy |
| Sigma-Aldrich | 42612 | Honokiol analytical standard | 35354-74-6 | 25MG | ₹14115.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 42612 | Honokiol analytical standard | 35354-74-6 | 25MG | ₹14115.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 384620 | Honokiol - CAS 35354-74-6 - Calbiochem A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. | 35354-74-6 | 10MG | ₹20000 | 2022-06-14 | Buy |
Honokiol Chemical Properties,Uses,Production
Description
Magnolol is derived from the root bark and branch bark of magnolia or Magnolia officinalis. Magnolia officinalis was first written in the《ben jing》, it prefers cool and humid climate and well-drained acid soil. Cortex magnoliae officinalis (hou po) is mainly produced in Sichuan (Wan quan, Shizhu, Guanxian), Hubei (Shien,Yichang, Lichuan), Zhejiang (Longquan, Anhui), and other places. It is also distributed in Fujian, Jiangxi, Hunan, Guangxi, Yunnan, Guizhou, Shanxi, Gansu, and other places. Cortex magnoliae officinalis from Sichuan and Hubei is called “chuan pu,” with better quality, while in Zhejiang, it is called “warm park,” with a larger output.
Physical properties
Appearance: white fine powder. Solubility: practically insoluble in water; very soluble in benzene, ethyl ether, chloroform, and acetone. Melting point: magnolol is 102 °C. Honokiol is 87.5 °C.
History
In 1930, magnolol was first isolated from the bark of Cortex magnoliae officinalis
in China by Japanese Sugii, and it was also isolated from Cortex magnoliae officinalis
in Japan. In 1973, magnolol and its isomers honokiol were isolated from Cortex magnoliae officinalis in China and Japan by Japanese Fujita.
The drug research and development of magnolol and honokiol remain in pharmacological activity and preclinical research. Kyung Hee University from Korea declared a preclinical study in 2003, in which allergy, anxiety, angina, and heart failure are indications for honokiol.
Uses
Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. Recent studies show that Honokiol displays antiangiogenic, antiinflammatory, and antitumor properties in preclinical models, w ithout appreciable toxicity. Honokiol has been shown to inhibit the bone metastatic growth of human prostate cancer cells.
Indications
These compounds are recorded in the British Pharmacopoeia (2017) and European Pharmacopoeia (8.7th ed.). They are mainly used as antibacterial and antifungal agents.
General Description
Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.
Pharmacology
Magnolol and honokiol have the pharmacological effects of prolonging central muscle relaxation, inhibition of the central nervous, anti-inflammatory, antibacterial, antimicrobial, antiulcer, antioxidant, antitumor, hormone regulation, and antidiabetes .
Honokiol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Natcon Biolife Sciences Pvt. Ltd. | 08046065751 | Delhi, India | 14 | 58 | Inquiry |
| Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213302 +86-18374838656 | China | 1027 | 58 | Inquiry |
| PNP Biotech Co. Ltd | +8618516098983 | China | 1001 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | China | 8808 | 58 | Inquiry |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | China | 12809 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | China | 5868 | 58 | Inquiry |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | China | 3005 | 58 | Inquiry |
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