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LY 223982

LY 223982 Structure
CAS No.
117423-74-2
Chemical Name:
LY 223982
Synonyms
CGS23131;LY 223982;SKF107324);LY223982,LY-223982;LY223982 Exclusive;SYZSSLLFRVDRHL-QPJJXVBHSA-N;LY223982 (Synonyms: CGS23131;5-(3-Carboxybenzoyl)-2-[(E)-6-(4-methoxyphenyl)-5-hexenyloxy]benzenepropanoic acid;Benzenepropanoic acid, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-
CBNumber:
CB21341434
Molecular Formula:
C30H30O7
Molecular Weight:
502.55
MOL File:
117423-74-2.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:02
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LY 223982 Properties

Melting point 151-152 °C
Boiling point 753.8±60.0 °C(Predicted)
Density 1.235±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Chloroform (Slightly, Heated, Sonicated), DMSO (Very Slightly)
form A crystalline solid
pka 3.81±0.10(Predicted)
color White to off-white

LY 223982 Chemical Properties,Uses,Production

Description

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. The benzophenone dicarboxylic acid derivative LY223982 is a potent BLT1 receptor antagonist. It inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 13.2 nM. LY223982 inhibits the leukotriene B4 (LTB4)-induced aggregation of guinea pig and human neutrophils with IC50 values of 74 and 100 nM, respectively. However, concentrations of LY223982 up to 10 μM do not inhibit binding of LTB4 to human BLT1 or BLT2 expressed in CHO cells.

Uses

LY223982 is a potent P2Y7 (BLT1) receptor antagonist.

LY 223982 Preparation Products And Raw materials

Raw materials

Preparation Products

LY 223982 Suppliers

Global( 35)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9707 58 Inquiry
DC Chemicals 021-58447131 13564518121 China 9412 58 Inquiry
United States Biological 1-800-520-3011 United States 6106 58 Inquiry
ApexBio Technology + 1-832-696-8203 United States 6254 58 Inquiry
Beijing Zhijie Fangyuan Technology Co., Ltd. 010-82897201 15810200961 CHINA 6984 58 Inquiry
Shanghai Minmin Biotechnology Co., Ltd. 18021003406 CHINA 6530 58 Inquiry
Xiamen Research Biotechnology Co., Ltd. 0592-6020891 18906011628 CHINA 6942 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Cayman Chemical Company 81
Shanghai EFE Biological Technology Co., Ltd. 58
DC Chemicals 58
United States Biological 58
ApexBio Technology 58
Beijing Zhijie Fangyuan Technology Co., Ltd. 58
Shanghai Minmin Biotechnology Co., Ltd. 58
Xiamen Research Biotechnology Co., Ltd. 58

117423-74-2(LY 223982)Related Search:

LY 223982 3-(3-FORMYLPHENYL)PROPANOIC ACID METHOXYPHENONE 4-METHOXY-3'-METHYLBENZOPHENONE 3-(2-METHOXYPHENYL)PROPIONIC ACID
LY 223982 5-(3-Carboxybenzoyl)-2-[(E)-6-(4-methoxyphenyl)-5-hexenyloxy]benzenepropanoic acid SYZSSLLFRVDRHL-QPJJXVBHSA-N LY223982 Exclusive LY223982 (Synonyms: CGS23131 SKF107324) CGS23131 Benzenepropanoic acid, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]- LY223982,LY-223982 117423-74-2