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ChemicalBook > Product Catalog >Organic Chemistry >Organic fluorine compound >2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid

2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid

2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid Structure
CAS No.
391211-97-5
Chemical Name:
2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid
Synonyms
2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid;3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid;2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic acid 98%;3,4-Difluoro-2-(2-fluoro-4-iodophenylaMino)benzoic Acid;3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)aMino]benzoic Acid;Benzoic acid, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]-;2-(N-2''-FLURO-4''-IODOPHENYL)AMINO-3,4-DIFLUORO BENZOIC ACID;2-(N-2''-FLURO-4''-IODOPHENYL)AMINO-3,4-DIFLUORO BENZOIC ACID;3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)benzoic acid
CBNumber:
CB21507957
Molecular Formula:
C13H7F3INO2
Molecular Weight:
393.1
MOL File:
391211-97-5.mol
Modify Date:
2024/3/27 11:02:23
Request For Quotation

2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid Properties

Melting point 189-191°C
Boiling point 370.1±42.0 °C(Predicted)
Density 1.939±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO (Sparingly), Methanol (Slightly)
form Solid
pka 3.25±0.36(Predicted)
color Off-White to Beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2916399090

2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Intermediate in the preparation of MEK inhibitors.

Synthesis

To a solution of methyl-3,4-diflluoro-2-((2-flluoro-4-iodophenyl)amino)benzoate (23, 6.0 g, 23.8 mmol) in methanol (80 mL) and water (80 mL) was added LiOH (7.8 g, 195 mmol). The reaction mixture was stirred at 78 C in an oil bath for 1 h. After cooling, the reaction mixture was acidified to pH = 2 with a 2 N HCl solution. The solid was filtered and washed with water to provide 2-(2-Fluoro-4-iodoanilino)-3,4-difluoro benzoic Acid (5.11 g, 96%) as a white solid.
2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid

2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid Preparation Products And Raw materials

Raw materials

2,3,4-Trifluorobenzoic acid 2-Fluoro-4-iodoaniline

Preparation Products

2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid Suppliers

Global( 98)Suppliers
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A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Yangzhou Qinyuan Pharmatech Co.,ltd +86-18752526868 China 71 58 Inquiry
Fluoropharm Co., Ltd. +86-0571-85586753; +8613336034509 China 1377 60 Inquiry
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Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Yangzhou Qinyuan Pharmatech Co.,ltd 58
Fluoropharm Co., Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Accela ChemBio Inc. 58
Chongqing Chemdad Co., Ltd 58
Shanghai Yingrui Biopharma Co.,Ltd 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 58

391211-97-5(2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid)Related Search:

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3-FLUORODIPHENYLAMINE 2-AMINO-3,4-DIFLUOROBENZOIC ACID
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2-(N-2''-FLURO-4''-IODOPHENYL)AMINO-3,4-DIFLUORO BENZOIC ACID 2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic Acid 3,4-Difluoro-2-(2-fluoro-4-iodophenylaMino)benzoic Acid 3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)aMino]benzoic Acid Benzoic acid, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]- 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid 2-(2-Fluoro-4-iodoanilino)-3,4-difluorobenzoic acid 98% 2-(N-2''-FLURO-4''-IODOPHENYL)AMINO-3,4-DIFLUORO BENZOIC ACID 3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)benzoic acid 391211-97-5 C13H7F3INO2 Aromatics Intermediates & Fine Chemicals Pharmaceuticals