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N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE

N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE Structure
CAS No.
2842-44-6
Chemical Name:
N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE
Synonyms
FirstCure MHPT;2-(N-Methyl-p-toluidino);HYDROXYETHYL METHYLTOLUIDINE;Hydroxyethyl methyltolylamine;2-(N-methyl-p-toluidino)ethanol;2-(Methyl(p-tolyl)aMino)ethanol;N-methyl-hydroxyethyl-p-toluidine;2-(N-Methyl-N-4-tolylamino)ethanol;2-(N-methyl-N-p-tolylamino)ethanol;2-(Methyl(p-tolyl)amino)ethan-1-ol
CBNumber:
CB2158428
Molecular Formula:
C10H15NO
Molecular Weight:
165.23
MOL File:
2842-44-6.mol
MSDS File:
SDS
Modify Date:
2024/9/4 16:41:34
Request For Quotation

N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE Properties

Boiling point 152-154 °C(Press: 10 Torr)
Density 1.047±0.06 g/cm3(Predicted)
vapor pressure 0.062-0.115Pa at 20-25℃
storage temp. Sealed in dry,Room Temperature
form Liquid:viscous
pka 14.69±0.10(Predicted)
InChI InChI=1S/C10H15NO/c1-9-3-5-10(6-4-9)11(2)7-8-12/h3-6,12H,7-8H2,1-2H3
InChIKey HXCWOOAEAHVMBJ-UHFFFAOYSA-N
SMILES C(O)CN(C)C1=CC=C(C)C=C1
LogP 2.2 at 25℃ and pH6
EPA Substance Registry System Ethanol, 2-[methyl(4-methylphenyl)amino]- (2842-44-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933599590

N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE Chemical Properties,Uses,Production

Uses

N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE is an amine organic compound, which can be used as intermediate in organic synthesis.

Synthesis

Add reactant (0.2 mmol, 1.0 equiv), THF (2.0 mL) and CH2Br2 (0.6 mmol, 3.0 equiv) to a flame-dried 10 mL Schlenk tube in a glove box. Seal and take out of the glove box. Cool the reaction mixture to -78°C. Add nBuLi (0.56 mmol, 2.8 equiv) dropwise under N2 atmosphere within 3minutes. Stir the reaction at -78°C for 30 minutes and add ZnCl2 (0.1 mL, 0.5equiv, 1.0 M in Et2O). Allow the mixture to warm to room temperature and stir for 1 hour. Cool the mixture to 0°C. Add a premixture of H2O2 (30% in H2O, 0.5 mL) and NaOH (2.0 M, 1.0 mL). Stir the mixture at room temperature for another 1 hour and dilute with water (20 mL). Extract with DCM (30 mL x 2) and dry over Na2SO4. Filter and concentrate under vacuum. Purify the crude product by silica gel flash column chromatography to obtain product. 1H NMR (CDCl3, 500 MHz) δ 7.08 (d, J = 8.4 Hz, 2H), 6.78 (d, J = 8.4 Hz,2H), 3.80 (t, J = 5.6 Hz, 2H), 3.43 (t, J = 5.4 Hz, 2H), 2.93 (s, 3H), 2.28 (s, 3H), 2.01 (brs, 1H). 13C NMR (CDCl3, 125 MHz) δ 148.3, 129.8, 127.1, 114.0, 60.1, 56.2, 39.1, 20.4.
synthetic method of N-(2-hydroxyethyl)-N-methyl-4-toluidine Fig The synthetic method of N-(2-hydroxyethyl)-N-methyl-4-toluidine

N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE Preparation Products And Raw materials

Raw materials

N-METHYL-P-TOLUIDINE Glycerol 2-Methylaminoethanol 4-Iodotoluene

Preparation Products

N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE Suppliers

Global( 146)Suppliers
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Yancheng Green Chemicals Co.,Ltd +undefined-86-25-86655873 China 114 58 Inquiry
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Finetech Industry Limited +86-27-87465837 +8618971612321 China 9640 58 Inquiry
Hebei Mojin Biotechnology Co., Ltd +86 13288715578 +8613288715578 China 12447 58 Inquiry
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Hefei TNJ Chemical Industry Co.,Ltd. +86-0551-65418679 +8618949832763 China 2989 55 Inquiry
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Supplier Advantage
Yancheng Green Chemicals Co.,Ltd 58
Changde Changlian Chemical Co., Ltd. 58
Finetech Industry Limited 58
Hebei Mojin Biotechnology Co., Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
Hangzhou FandaChem Co.,Ltd. 55
Anhui Royal Chemical Co., Ltd. 55
Hefei TNJ Chemical Industry Co.,Ltd. 55
Hebei Guanlang Biotechnology Co., Ltd. 58
Xiamen AmoyChem Co., Ltd 58

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