2-Fluoro-4-hydroxybenzaldehyde
- CAS No.
- 348-27-6
- Chemical Name:
- 2-Fluoro-4-hydroxybenzaldehyde
- Synonyms
- 3-Fluoro-4-formylphenol;2-Fluoro-6-nitroacetophenone;2-FLURO-4-HYDROXYBENZALDEHYDE;2-FLUORO-4-HYDROXYBENZALDEHYDE;Benzaldehyde, 2-fluoro-4-hydroxy-;2-Fluoro-4-hydroxybenzaldehyde,98%
- CBNumber:
- CB2214861
- Molecular Formula:
- C7H5FO2
- Molecular Weight:
- 140.11
- MOL File:
- 348-27-6.mol
- Modify Date:
- 2024/4/8 13:48:25
| Melting point | 168-170°C |
|---|---|
| Boiling point | 254.2±20.0 °C(Predicted) |
| Density | 1.350±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | crystalline powder |
| pka | 6.78±0.18(Predicted) |
| color | Light tan |
| InChI | InChI=1S/C7H5FO2/c8-7-3-6(10)2-1-5(7)4-9/h1-4,10H |
| InChIKey | ONRPXRPUBXXCCM-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC=C(O)C=C1F |
| CAS DataBase Reference | 348-27-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-37/38-41-52 | |||||||||
| Safety Statements | 26-39 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2912490090 | |||||||||
| NFPA 704 |
|
2-Fluoro-4-hydroxybenzaldehyde price More Price(2)
2-Fluoro-4-hydroxybenzaldehyde Chemical Properties,Uses,Production
Uses
2-Fluoro-4-hydroxybenzaldehyde is a useful reagent for preparation of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.
Uses
2-Fluoro-4-hydroxybenzaldehyde is mainly used as an intermediate for physiologically active compounds such as pharmaceuticals or pesticides and is a wide range of organic building blocks. Its structure contains fluorine, aldehyde groups, and phenolic hydroxyl groups, and these groups can add or replace other functional groups.
Synthesis
Preparation of 2-fluoro-4-hydroxybenzaldehyde involves: (1) mixing 3-fluorophenol (I), potassium carbonate, and 2-bromopropane in an organic solvent, and heating to react to obtain 1-fluoro-3-isopropoxybenzene (II); (2) dissolving compound (II) in an organic solvent and reacting with a brominating reagent to obtain 1-bromo-2-fluoro-4-isopropoxybenzene (III); (3) dissolving compound (III) in tetrahydrofuran, dripping isopropylmagnesium chloride/tetrahydrofuran solution at -10°C to 0°C, adding dimethylformamide to react after Grignard exchange to obtain 2-fluoro-4-isopropoxybenzaldehyde (IV); and (4) reacting compound (IV) with boron trichloride and deprotecting.
2-Fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GOALSY PHARMA | +91-8247562464 +91-9885583385 | Hyderabad, India | 479 | 58 | Inquiry |
| SL Drugs and Pharmaceuticals Pvt. Ltd. | +91 (40) 6661-1133 | New Delhi, India | 2688 | 50 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Chemit Laboratories | 08047646230 | Hyderabad, India | 288 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12459 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20361 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Supplier | Advantage |
|---|---|
| GOALSY PHARMA | 58 |
| SL Drugs and Pharmaceuticals Pvt. Ltd. | 50 |
| A.J Chemicals | 58 |
| Alfa Aesar | 58 |
| Reax Chemicals | 58 |
| Chemit Laboratories | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Hebei Mojin Biotechnology Co., Ltd | 58 |
| Henan Fengda Chemical Co., Ltd | 58 |
| Capot Chemical Co.,Ltd. | 60 |
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