Epinastine
- CAS No.
- 80012-43-7
- Chemical Name:
- Epinastine
- Synonyms
- WAL801;CS-1366;EPINASTINE;ELESTAT;WAL801;Apinastine Base;EPINASTINE BASE;Epinastine (WAL801);Epinastine USP/EP/BP;Epinastine in methanol;9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3- amine
- CBNumber:
- CB2230197
- Molecular Formula:
- C16H15N3
- Molecular Weight:
- 249.31
- MOL File:
- 80012-43-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:03
| Melting point | 205-208° |
|---|---|
| Boiling point | 428.0±55.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO : ≥ 50 mg/mL (200.55 mM);Water : < 0.1 mg/mL (insoluble) |
| pka | 11.2(at 25℃) |
| form | Solid |
| color | White to off-white |
| CAS DataBase Reference | 80012-43-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H411-H372 |
| Precautionary statements | P273-P280 |
Epinastine Chemical Properties,Uses,Production
Description
Epinastine hydrochloride, an orally active antihistaminic agent, was marketed in Japan for the treatment of bronchial asthma, allergic rhinitis, urticaria, eczema, dermatitis, and psoriasis vulgaris.Epinastine is one of the most effective peripherally acting histamine H1-receptor antagonists without sedative effects.In addition, it exhibits potent anti-PAF and anti-LT activity which may also contribute significantly to its antiallergic activity. Chronic epinastine has been reported to effectively inhibit airway hyper-responsiveness in rats. Potent inhibitory effects of epinastine on bronchoconstriction induced by histamine and bradykinin, but not by other chemical mediators, has also been reported. Studies have indicated that there are no significant differences in pharmacological properties among D-, L-, and racemic epinastine.
Uses
Epinastine is antihistamine and mast cell stabilize that is used in eye drops for the treatment of allergic conjunctivitis.
Definition
ChEBI: A benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine.
Clinical Use
Epinastine is a potent, long-acting H1 antihistamine and an inhibitor of the release of histamine and other transmitters from mast cells. It has some affinity for H2 receptors as well. It is used as an eye drop for allergic conjunctivitis. It does not penetrate into the CNS and is classified as a nonsedating antihistamine.
Epinastine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| aistrifarma | +91-6374274350 +91-7708086868 | Tamil Nadu, India | 15 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Akshara Eye Hospital | 08069033787Ext 967 | Karnataka, India | 2 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21677 | 55 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | China | 2234 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12460 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
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