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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Structure
CAS No.
1156491-10-9
Chemical Name:
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride
Synonyms
(1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride;(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1);(1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride;Ticagrelor USP RC A;Ticagrelor side chain 2 hydrochloride;2-(3,4-Difluoro-phenyl)-cyclopropylamine;(1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami;(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl
CBNumber:
CB22498775
Molecular Formula:
C9H10ClF2N
Molecular Weight:
205.63
MOL File:
1156491-10-9.mol
Modify Date:
2024/12/24 18:06:02
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(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Properties

Melting point >172°C (dec.)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White
InChI InChI=1/C9H9F2N.ClH/c10-7-2-1-5(3-8(7)11)6-4-9(6)12;/h1-3,6,9H,4,12H2;1H/t6-,9+;/s3
InChIKey IMYLOCHFFLYHPS-RHUSADAZNA-N
SMILES N[C@@H]1C[C@H]1C1C=CC(F)=C(F)C=1.Cl |&1:1,3,r|

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Chemical Properties,Uses,Production

Synthesis Reference(s)

Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts. EU Patent EP2644590A1

Synthesis

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine1,2-Difluorobenzene is reacted with 3-chloropropionyl chloride to produce 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one, which is by addition of N,N-dimethylformamide, phloroglucinol and sodium iodide in the next step converted to 1-(3',4'-difluorophenyl)-3-nitro-propan-1-one. The keto group of the latter intermediate is in the subsequent step stereochemically reduced to hydroxyl group by the use of chiral oxazaborolidine together with borane dimethyl sulfide or borane-N,N-diethyl aniline complex in the presence of tetrahydrofurane. The obtained (1R)-1-(3',4'-difluorophenyl)-3-nitro-propan-1-ol is then added to a mixture of triphenylphosphine and diethylazodicarboxylate in benzene to yield (1S,2R)-2-(3',4'-difluorophenyl)-1-nitrocyclopropane, which is in the last step converted to 2-(3,4-difluorophenyl)cyclopropane amine by reduction of the nitro group by catalytic hydrogenation with palladium catalyst and zink dust. 

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Suppliers

Global( 259)Suppliers
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BTC pharm India 58
Vijayasri Organics Private Limited 58
Credas Labs Pvt Ltd 58
JSK Chemicals 58
CHEMSWORTH 30
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Trignokem International 50
Shanghai Safer Pharmaceutical Technology Co., Ltd. 58

1156491-10-9((1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride)Related Search:

Canagliflozin Tetrahydro-2,2-dimethyl-4,7-methano-6H-1,3-dioxolo[4,5-d][1,2]oxazine-6-carboxylic acid phenylmethyl ester 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride 1-[2-Amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol hydrochloride 4-(4-Methylpiperazinylmethyl)benzoyl chloride dihydrochloride
TICAGRELOR 2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol L-tataric acid 4,6-dichloro-2-propylthiopyrimidine-5-amine 4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate 1-Acetyladamantane Intermediate (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine. HCl Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH)
(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide CarbaMicacid,N-[(3aS,4R,6S,6aR)-tetrahydro-6-hydroxy-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]-,phenylMethyl ester Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1)
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(1R,2S)-2-(3,4-Difluorophenyl)-cyclopropan-1-aMine HCL (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami 2-(3,4-Difluoro-phenyl)-cyclopropylamine (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine CYCLOPROPANAMINE, 2-(3,4-DIFLUOROPHENYL)-, HYDROCHLORIDE (1:1), (1R,2S)-REL- trans-(1R,2S)-2-(3,4-difluorphenyl)cyclopropylaMine (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine HCl (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochlorideQ: What is (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride Q: What is the CAS Number of (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride Q: What is the storage condition of (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine hydrochl... (1R,2S)-REL-2-(3,4-difluorophenyl)cyclopropane amine chloride Ticagrelor side chain 2 hydrochloride trans-rel-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride Ticagrelor USP RC A trans-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride (1R,2S)-2-(3,4-difluorophenyl)cyclopropane amine hydrochloride trans-(1R,2S)-2-(3,4-Diflurophenyl)cyclopropylamine hydrochloride (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1) (1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride (1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine (1R,2S)-2-(3,4-Diflurophenyl)cyclopropylamine hydrochloride, (1R,2S)-rel-2-(3,4-Difluorophenyl)-cyclopropanamine hydrochloride (1:1) (1R, 2S) - REL-2- (3,4-difluorophenyl) cyclopropylamine hydrochloride 1R trans)-2-(3,4-difluorophenyl)cyclopropane amine in stock (1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochlo trans)-2-(3,4-difluorophenyl)cyclopropane amine hydrochloride (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine hydrochloride (1R,2S)-Rel-2-(3,4-Difluorophenyl)-Cyclopropanamine Hydr 1156491-10-9 C9H9F2NHCl Intermediate of Ticagrelor 1156491-10-9