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TICAGRELOR

TICAGRELOR Structure
CAS No.
274693-27-5
Chemical Name:
TICAGRELOR
Synonyms
Brilinta;(1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(4-fluoro-3-(methylthio)phenyl) cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol;AZ13265501;Ticargrelor;Tecagrelor;Ticagrelore;Bentracimab;Ticag;Tigre;Possia
CBNumber:
CB51509134
Molecular Formula:
C23H28F2N6O4S
Molecular Weight:
522.57
MOL File:
274693-27-5.mol
Modify Date:
2024/8/22 14:21:17
Request For Quotation

TICAGRELOR Properties

Melting point 138-140°C
Boiling point 777.6±70.0 °C(Predicted)
Density 1.67
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Methanol (Slightly)
pka 13.26±0.70(Predicted)
form Solid
color White to Off-White
Stability Hygroscopic
InChIKey OEKWJQXRCDYSHL-FNOIDJSQSA-N
SMILES [C@@H]1(O)[C@@H](OCCO)C[C@@H](N2C3C(N=N2)=C(N[C@@H]2C[C@H]2C2=CC=C(F)C(F)=C2)N=C(SCCC)N=3)[C@@H]1O

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H319-H411
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P
Safety Statements  24/25
HS Code  29335990
NFPA 704
0
2 0

TICAGRELOR price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML2482 Ticagrelor ≥98% (HPLC) 274693-27-5 10MG ₹6016.2 2022-06-14 Buy
Sigma-Aldrich(India) SML2482 Ticagrelor ≥98% (HPLC) 274693-27-5 50MG ₹12154.5 2022-06-14 Buy
Product number Packaging Price Buy
SML2482 10MG ₹6016.2 Buy
SML2482 50MG ₹12154.5 Buy

TICAGRELOR Chemical Properties,Uses,Production

Description

In December 2010, the P2Y12 receptor antagonist ticagrelor (also known as AZD6140) was approved in Europe for the treatment of acute coronary syndrome (ACS), a condition that covers several clinical symptoms with the potential to cause acute myocardial ischemia (MI). ADP binds to two purinergic receptors, the P2Y1 and P2Y12 receptors. The action of ADP binding to the P2Y12 receptor results in activation of the GP Ⅱb/Ⅲa (integrin) receptor.GP Ⅱb/Ⅲa initiates and prolongs platelet aggregation, which in turn results in the cross-linking of platelets through fibrin and finally thrombus formation. Inhibition of ADP stimulation of the P2Y12 receptor has been found to be an effective strategy for managing the atherothrombotic events associated with ACS and potentially resulting from percutaneous coronary intervention (PCI, stent implantation) .

Chemical Properties

White Solid

Definition

ChEBI: A triazolopyrimidine that is an adenosine isostere; the cyclopentane ring is similar to ribose and the nitrogen-rich [1,2,3]triazolo[4,5-d]pyrimidine moiety resembles the nucleobase adenine. A platelet aggregation inhibitor which is used for p evention of thromboembolic events in patients with acute coronary syndrome.

Clinical Use

Ticagrelor, discovered and developed by AstraZeneca, is a platelet adenosine diphosphate (ADP) P2Y12 (P2T) reversible receptor antagonist approved in the E.U. in 2010 and launched in Germany and the UK in 2011 for the treatment of patients with acute coronary syndromes (ACS). It was approved in the U.S. and Canada in 2011 following successful clinical trial results in patients with ACS which showed it to be superior to preexisting drugs for reducing death due to vascular causes. Ticagrelor is an oral drug indicated for use in combination with acetylsalicylic acid (aspirin) for the prevention of atherothrombotic events in adult patients with ACS (unstable angina, non-ST elevation myocardial infarction (NSTEMI), or ST elevation myocardial infarction (STEMI)). Unlike its competitors prasugrel and clopidogrel, which require bioactivation, ticagrelor is not a prodrug and does not require in vivo activation. It has a rapid onset of action, relatively rapid reversibility, greater potency, and exhibits consistency in platelet inhibition. Following dosing, ticagrelor reaches Cmax in about 1.5 h, with formation of a major metabolite with equipotent intrinsic activity to the parent compound.

TICAGRELOR Preparation Products And Raw materials

Raw materials

Preparation Products

2-[[(3aS,4R,6S,6aR)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol

TICAGRELOR Suppliers

Global( 653)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
HEMA PHARMACEUTICALS PVT LTD +91-9537936912 +91-9537936912 Gujarat, India 48 58 Inquiry
Saptagir Laboratories PVT.LTD. +91-9059978049 +91-9059978049 Telangana, India 31 58 Inquiry
SGMR PHARMACEUTICALS PVT LTD +91-9032001889 +91-9032001889 Telangana, India 83 58 Inquiry
J S LABS +91-7330612784 +91-7330612784 Tamil Nadu, India 160 58 Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
TYNDAL LABS PVT LTD +91-8008166674 +91-8008166674 AndhraPradesh, India 95 58 Inquiry
Lewens Labs +917043057100 Gujarat, India 30 58 Inquiry
KARUNESH REMEDIES +919998776849 Gujarat, India 18 58 Inquiry
Honour Lab Limited +919845977466 Telangana, India 164 58 Inquiry
Bajaj Healthcare Ltd +91-2266177400 +91-2266177400 Maharashtra, India 86 58 Inquiry
Supplier Advantage
HEMA PHARMACEUTICALS PVT LTD 58
Saptagir Laboratories PVT.LTD. 58
SGMR PHARMACEUTICALS PVT LTD 58
J S LABS 58
Dr. Reddy's Laboratories Ltd 58
TYNDAL LABS PVT LTD 58
Lewens Labs 58
KARUNESH REMEDIES 58
Honour Lab Limited 58
Bajaj Healthcare Ltd 58

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Related Qustion

  • Q:Is ticagrelor same as Plavix ?
  • A:Brilinta (ticagrelor) and Plavix (clopidogrel) are used to prevent blood clots in patients with heart issues and reduce the ri....
  • Jun 7，2024

TICAGRELOR Spectrum

TICAGRELOR(274693-27-5)1HNMR

274693-27-5(TICAGRELOR)Related Search:

Prasugrel Clopidogrel (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) Ticagrelor IMpurity E
2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol L-tataric acid 4,6-dichloro-2-propylthiopyrimidine-5-amine (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
CarbaMicacid,N-[(3aS,4R,6S,6aR)-tetrahydro-6-hydroxy-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]-,phenylMethyl ester Everolimus Y27632 (hydrochloride) Selumetinib MK-2206 2HCl
ABT 263 PLX4032 Ticagrelor Sulfone
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1,2-Cyclopentanediol, 3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)- Ticagrelor, >=98% Ticagrelo Ticarelor Brilique (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol TICAGRELOR (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol Azd 6140 Unii-glh0314rvc (1S,2S,3R,5S)-3-(7-(((1S,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol AR-C 126532XX Ticagrelor(AR-C 126532XX Ticagrelor (AZD6140) (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-difluorophenyl)cyclopropylaMino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-D1,2-Cyclopentanediolifluorophenyl)cyclopropyl]aMino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyriMidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol 3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]aMino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyriMidin-3-yl]-5-(2-hydroxyethoxy)-,(1S,2S,3R,5S)- (1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropylaMino]-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol Possia Ticagrelor and intermediates Ticagrelor Standards Tikagre Ticagrel Ticagrelor Impurity 81 Ticagrelor (Brilinta,AZD6140) CS-256 AZD-6140; TICAGRELOR ; BRILINTA; AZD 6140 1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol Ticagrelor standard Ticag (1S,2S,3R,5S)-3-(7-(((1R)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol icagrelor TICAGRELOR USP/EP/BP Ticagrelor Form Ⅱ (1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropy... Ticagrelor for system suitability (Y0002223)Q: What is Ticagrelor for system suitability (Y0002223) Q: What is the CAS Number of Ticagrelor for system suitability (Y0002223) TicagrelorQ: What is Ticagrelor Q: What is the CAS Number of Ticagrelor Q: What is the storage condition of Ticagrelor Q: What are the applications of Ticagrelor Ticargrelor Brilinta (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(4-fluoro-3-(methylthio)phenyl) cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol AZ13265501 Ticagrelore Bentracimab Tecagrelor Tigre Research Grade Bentracimab (DGK10801) Tegrelo Ticagagrel Ticagrelor IP/BP/EP Tigrillo Ticagrelor Form Ⅱ Ticagrelor IP 274693-27-5 374693-27-5 74693-27-5 C23H28F2N6O4S AZD6140 Ticagrelor