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lurasidone

lurasidone Structure
CAS No.
367514-87-2
Chemical Name:
lurasidone
Synonyms
CS-327;urasidone;lurasidone;Lurasindone;Lurasidone Base;Lurasidone, >=98%;Lurasidone (SM13496);lurasidone USP/EP/BP;Lurasidone Free base;TIANFU-CHEM - lurasidone
CBNumber:
CB22498821
Molecular Formula:
C28H36N4O2S
Molecular Weight:
492.68
MOL File:
367514-87-2.mol
Modify Date:
2024/5/16 14:11:51
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lurasidone Properties

Melting point 146-149°C
Boiling point 623.4±55.0 °C(Predicted)
Density 1.273
storage temp. -20°C Freezer
solubility Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka 8.41±0.50(Predicted)
form Solid
color White to Off-White
InChIKey PQXKDMSYBGKCJA-CVTJIBDQSA-N
SMILES C1(=O)[C@]2([H])[C@@]([H])([C@]3([H])C[C@@]2([H])CC3)C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(C2C3=C(SN=2)C=CC=C3)CC1
CAS DataBase Reference 367514-87-2

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
NFPA 704
0
3 0

lurasidone Chemical Properties,Uses,Production

Description

The atypical antipsychotic lurasidone (also known as SM-13496) was approved in the United States in 2010 as an oral agent for the treatment of patients with schizophrenia. Lurasidone has potent affinity for D2 (Ki= 1.7 nM) and 5-HT2A (Ki= 2.0 nM) receptors and acts as an antagonist at both receptors. It is also a partial agonist at the 5-HT1A receptor and, unlike other atypical agents, is a potent antagonist at the 5-HT7 receptor; both of these activities are thought to confer beneficial cognitive properties. Lurasidone is further differentiated by its lack of affinity for muscarinic and histamine H1 receptors and its weak affinity for the 5-HT2C receptor. Antagonism at H1 and 5-HT2C receptors has been implicated in weight gain associated with atypical agents, while muscarinic receptor antagonism is associated with cognitive deficits.

Definition

ChEBI: An N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-m thanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizoph enia.

lurasidone Preparation Products And Raw materials

Raw materials

Preparation Products

lurasidone Suppliers

Global( 224)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
J S LABS +91-7330612784 +91-7330612784 Tamil Nadu, India 160 58 Inquiry
KARPSCHEM LABORATORIES +91-7249203006 +91-7249203006 Maharashtra, India 786 58 Inquiry
Glenmark Pharmaceuticals Limited +912240189999 Maharashtra, India 93 58 Inquiry
Macleods Pharmaceuticals Limited +91-2266762800 +91-2266762800 Maharashtra, India 116 58 Inquiry
Megafine Pharma +91 9867686666, +91 9665458868 Maharashtra, India 29 58 Inquiry
Ralington Pharma +91-7948911722 +91-9687771722 Gujarat, India 1350 58 Inquiry
Maps Laboratories Pvt Ltd +91-9925030826 +91-9925013085 Gujarat, India 28 58 Inquiry
Raks Pharma Pvt Ltd +91-8924671555 +91-8924671555 AndhraPradesh, India 31 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
MSN LABORATORIES PRIVATE LTD +91 40 30438600 New Delhi, India 230 58 Inquiry
Supplier Advantage
J S LABS 58
KARPSCHEM LABORATORIES 58
Glenmark Pharmaceuticals Limited 58
Macleods Pharmaceuticals Limited 58
Megafine Pharma 58
Ralington Pharma 58
Maps Laboratories Pvt Ltd 58
Raks Pharma Pvt Ltd 58
CLEARSYNTH LABS LTD. 58
MSN LABORATORIES PRIVATE LTD 58

lurasidone Spectrum

lurasidone(367514-87-2)1HNMR

367514-87-2(lurasidone)Related Search:

ILOPERIDONE dihydro-o-xylene 3-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]-1,2-benzothiazole (3aR,4S,7R,7aS)-2-{(1R,2S)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylMethyl]cyclohexylMethyl}hexahydro-4,7-Methano-2H-isoindole-1,3-dione hydrochloride (3aR,4S,7R,7aS)-2-[[(1S,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione
MAVBUKOHERNHBQ-UHFFFAOYSA-N Lurasidone Impurity 24 MDYJLJKDGQUHSJ-HTWOXQOSSA-N Nsc237999 Lurasidone Impurity 2
Lurasidon hydrochloride iMpurity s,s-endo-lurasidone HCl Pregabalin Liraglutide Lurasidone hydrochloride
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4-{[(1R,2R)-2-{[4-(2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(11),2,4,7,9-pentaen-5-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}-4-azatricyclo[5.2.1.0^{2,6}]deca-1(9),2(6),7-triene-3,5-dione lurasidone (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione Lurasidone (SM13496) (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione urasidone Lurasidone, >=98% Lurasidone Base (3aR,4S,7R,7aS)-2-((1R,2R)-2-(4-(1,2-Benzothiazol-3-yl)piperazin-1-ylmethyl)cyclohexylmethyl)hexahydro-4,7-methano-2H-isoindole-1,3-dione CS-327 4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-, (3aR,4S,7R,7aS)- (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl]methyl]cyclohexyl]methyl]hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione lurasidone USP/EP/BP TIANFU-CHEM - lurasidone SM13496; SM-13496; SM 13496 Lurasidone Free base Lurasindone (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinylChemicalbook]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}hexahydro-1H-4 Lurasidone (3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3- yl)piperazin-1-yl)methyl) cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)- dione 367514-87-2 C28H36N4O2S Pharmaceutical intermediate