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2'-deoxy-2'-fluoro-2'-C-methylcytidine

2'-deoxy-2'-fluoro-2'-C-methylcytidine Structure
CAS No.
817204-33-4
Chemical Name:
2'-deoxy-2'-fluoro-2'-C-methylcytidine
Synonyms
ethyl 4-broMo-1-Methyl-1H-pyrrole-2-carboxylate;PSI 6130;R 1656;CS-1995;PSI-6130(R 1656);PSI-6130;PSI 6130;Sofosbuvir Impurity 121;PSI-6130, 10 mM in DMSO;PSI-6130;R 1656;PSI 6130;2'-Deoxy-2'-F-2'-C-methylcytidine
CBNumber:
CB22525888
Molecular Formula:
C10H14FN3O4
Molecular Weight:
259.23
MOL File:
817204-33-4.mol
MSDS File:
SDS
Modify Date:
2024/11/19 23:02:33
Request For Quotation

2'-deoxy-2'-fluoro-2'-C-methylcytidine Properties

Melting point 216-218℃
Boiling point 482.4±55.0 °C(Predicted)
Density 1.67
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Methanol (Slightly), Water (Slightly)
pka 12.86±0.70(Predicted)
form Solid
color White to Light Brown
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2'-deoxy-2'-fluoro-2'-C-methylcytidine Chemical Properties,Uses,Production

Description

PSI-6130 is a nucleoside inhibitor of the NS5B RNA polymerase of hepatitis C virus (HCV; Ki = 4.3 μM). It inhibits HCV genotype 1b (GT-1b) Con1 and GT-1a H77 viral replication in Huh7 replicon cells using a luciferase-based assay (EC50s = 0.51 and 0.30 μM, respectively). PSI-6130 also inhibits replication of HCV GT-1b and GT-1a replicons from clinical isolates, with EC50 values ranging from 0.60 to 1.41 μM, and 0.20 to 0.43 μM, respectively, in the same assay. It has little or no activity against West Nile Virus (WNV), Dengue type 2 virus (DV), human immunodeficiency virus (HIV), or hepatitis B virus (HBV; EC90s = 46.3, >100, >100, and >10 μM, respectively).

Uses

PSI-6130 is an experimental treatment for hepatitis C. PSI-6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors. PSI-6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B.

2'-deoxy-2'-fluoro-2'-C-methylcytidine Preparation Products And Raw materials

Raw materials

Preparation Products

2'-deoxy-2'-fluoro-2'-C-methylcytidine Suppliers

Global( 147)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
Henan Fengda Chemical Co., Ltd +86-371-86557731 +86-13613820652 China 20235 58 Inquiry
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 China 29730 60 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-+86-371-66670886 China 19809 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21628 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29859 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19552 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49732 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Henan Fengda Chemical Co., Ltd 58
Capot Chemical Co.,Ltd. 60
Shanghai Daken Advanced Materials Co.,Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
BOC Sciences 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58

817204-33-4(2'-deoxy-2'-fluoro-2'-C-methylcytidine)Related Search:

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(2'R)-2'-deoxy-2'-fluoro-2'-methyl-Cytidine PSI-6130;R 1656;PSI 6130 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyr 2'-deoxy-2'-fluoro-2'-C-methylcytidine R 1656 ethyl 4-broMo-1-Methyl-pyrrole-2-carboxylate 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimi 4-AMino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidin-2(1H)-one R 1656; R-1656; R1656; PSI6130; PSI 6130 2'-deoxy-2'-fluoro-2'-C-methylcytidin 2'-Deoxy-2'-F-2'-C-methylcytidine CS-1995 PSI-6130;PSI 6130 Cytidine, 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)- 2'-deoxy-2'-fluoro-2'-C-methylcytidine,817204-33-4 ethyl 4-broMo-1-Methyl-1H-pyrrole-2-carboxylate PSI 6130 2'-deoxy-2'-Fluoro-2'-methylcytidine 4-Amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one (sofosbuvir Impurity) Sofosbuvir Impurity 121 2'-C-methyl-2'-Fluoro-2'-deoxyCytidine PSI-6130(R 1656) (2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine PSI-6130, 10 mM in DMSO 817204-33-4 apis