ZK118182 isopropyl ester

CAS No.: 154927-31-8

Chemical Name:: ZK118182 isopropyl ester

Synonyms: ZK118182 isopropyl ester;QLJUNFBXIBNQOL-LMJZMJOFSA-N;ZK118182 isopropyl ester Exclusive;ZK118182 isopropyl ester,ZK-118182 isopropyl ester;propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate;Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI)

CBNumber:: CB22592893

Molecular Formula:: C23H37ClO5

Molecular Weight:: 428.99

MOL File:: 154927-31-8.mol

Modify Date:: 2023/7/12 17:07:11

Request For Quotation

ZK118182 isopropyl ester Properties

Boiling point	553.1±50.0 °C(Predicted)
Density	1.14±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
pka	14.22±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H225-H319-H336

Precautionary statements

P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501

NFPA 704

	3
2		0

ZK118182 isopropyl ester Chemical Properties,Uses,Production

Description

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF_2α and PGD₂, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC₅₀ = 16.5 nM) and a high nanomolar affinity for the DP receptor (K_i = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.

ZK118182 isopropyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

ZK118182 isopropyl ester Suppliers

Global( 18)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Cayman Chemical Company	(800) 364-9897	United States	6618	81	Inquiry
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	China	8740	58	Inquiry
Resenbio	029-86354885	China	1777	50	Inquiry
Morning Student Science and Technology (Guangzhou) Co., Ltd.	020-36048871 13760856740	CHINA	6618	58	Inquiry
Shanghai Chaoyan Biotechnology Co., Ltd.	021-50840550	CHINA	6217	58	Inquiry
Shanghai Benrui Biotechnology Co., Ltd.	13917534498	CHINA	1472	58	Inquiry
Shanghai Jijin Chemical Technology Co., Ltd.	400-002-6926 15900443528	CHINA	6617	58	Inquiry
Boao Pike	010-57798038 15652371397	CHINA	6629	58	Inquiry
Absin Bioscience Inc.	021-38015121	CHINA	6661	58	Inquiry

Supplier	Advantage
TargetMol Chemicals Inc.	58
Cayman Chemical Company	81
Shanghai Yifei Biotechnology Co. , Ltd.	58
Resenbio	50
Morning Student Science and Technology (Guangzhou) Co., Ltd.	58
Shanghai Chaoyan Biotechnology Co., Ltd.	58
Shanghai Benrui Biotechnology Co., Ltd.	58
Shanghai Jijin Chemical Technology Co., Ltd.	58
Boao Pike	58
Absin Bioscience Inc.	58

154927-31-8(ZK118182 isopropyl ester)Related Search:

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ZK 110841 ZK 112993 FUDAEUIGIJZUAY-UMIRZPQISA-N ZK-261991

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ZK118182 isopropyl ester Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI) propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate ZK118182 isopropyl ester Exclusive QLJUNFBXIBNQOL-LMJZMJOFSA-N ZK118182 isopropyl ester,ZK-118182 isopropyl ester 154927-31-8 C23H37ClO5