[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane

CAS No.: 536975-50-5

Chemical Name:: [difluoro(phenylsulfonyl)Methyl]triMethyl-Silane

Synonyms: Difluoro(trimethylsilyl)methyl]sulfonyl]-benzene;[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane;Benzene, [[difluoro(trimethylsilyl)methyl]sulfonyl]-

CBNumber:: CB22644992

Molecular Formula:: C10H14F2O2SSi

Molecular Weight:: 264.36

MOL File:: 536975-50-5.mol

Modify Date:: 2024/1/22 11:46:46

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[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane Properties

Boiling point	96-97 °C(Press: 1 Torr)
Density	1.162±0.06 g/cm3(Predicted)

SAFETY

Risk and Safety Statements

Safety Statements	24/25
HS Code	29350090

[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane Chemical Properties,Uses,Production

Description

A much milder difluoro(phenylsulfonyl)methylation reagent than difluoromethyl phenyl sulfone. Under the action of Lewis bases such as such as tetrabutylammonium triphenyldifluorosilicate (TBAT), potassium fluoride, potassium hydrodifluoride, and potassium carbonate, difluoro(phenylsulfonyl)methyl can be transferred to aldehydes, ketones, alkyl halides, and non-activated imines.

Reactions

(1) Difluoromethylation of aldehydes and ketones.

(2) Difluoromethylation of alkyl halides.

(3) Difluoromethylation of imines and enamines.

References

[1] H. TOMIOKA. Selective oxidation of a primary hydroxyl in the presence of secondary one[J]. Tetrahedron Letters, 1981, 49 1: 1605-1608. DOI:10.1016/S0040-4039(01)90389-2
[2] LINGUI ZHU. Nucleophilic (phenylsulfonyl)difluoromethylation of alkyl halides using PhSO2CF2SiMe3: preparation of gem-difluoroalkenes and trifluoromethyl compounds[J]. Tetrahedron Letters, 2010, 51 47: Pages 6150-6152. DOI:10.1016/j.tetlet.2010.09.068.
[3] MIKHAIL D. KOSOBOKOV. Reactions of Sulfur- and Phosphorus-Substituted Fluoroalkylating Silicon Reagents with Imines and Enamines under Acidic Conditions[J]. The Journal of Organic Chemistry, 2012, 77 4: 2080-2086. DOI:10.1021/jo202669w.

[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane Preparation Products And Raw materials

Raw materials

Preparation Products

DifluoroiodoMethyl phenyl sulfone

[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane Suppliers

Global( 22)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	16858	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23556	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry
Zhengzhou Acme Chemical Co., Ltd.	0371-0371-55629727 13323845623	China	9859	58	Inquiry
Ningbo Chemrio Chemtech Co,.Ltd.	0574-27891269 18667892864	China	3620	58	Inquiry
TCI (Shanghai) Chemical Trading Co., Ltd.	021-021-61109150	China	31163	58	Inquiry
JinJin Le Chemical Co., Ltd	10106090	China	9981	58	Inquiry
Shanghai Silan Pharmaceutical Technology Co. , Ltd.	17301772648	China	386	58	Inquiry
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 18112977050	China	10529	58	Inquiry
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	China	7176	65	Inquiry

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
ANHUI WITOP BIOTECH CO., LTD	58
Amadis Chemical Company Limited	58
Zhengzhou Acme Chemical Co., Ltd.	58
Ningbo Chemrio Chemtech Co,.Ltd.	58
TCI (Shanghai) Chemical Trading Co., Ltd.	58
JinJin Le Chemical Co., Ltd	58
Shanghai Silan Pharmaceutical Technology Co. , Ltd.	58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	58
Daicel Chiral Technologies (China)CO.,LTD	65

[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane Difluoro(trimethylsilyl)methyl]sulfonyl]-benzene Benzene, [[difluoro(trimethylsilyl)methyl]sulfonyl]- 536975-50-5 C10H14F2O2SSi