Ibrutinib Impurity 9

2-Propen-1-one, 1-[4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinyl]- Ibrutinib Impurity 28 Ibrutinib Dimer Impurity (S)-Ibrutinib (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one

Ibrutinib Impurity 13 Ibrutinib Impurity 4 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine Ibrutinib Impurity 6 Ibrutinib Impurity 12

Ibrutinib Impurity 3 (S)-1-Boc-3-hydroxypiperidine Ibrutinib Impurity 14 (R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-chloropropan-1-one Ibrutinib Impurity 11

Ibrutinib Impurity 2 Ibrutinib Ibrutinib Impurity 10