ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >(S)-1-Boc-3-hydroxypiperidine
(S)-1-Boc-3-hydroxypiperidine
- CAS No.
- 143900-44-1
- Chemical Name:
- (S)-1-Boc-3-hydroxypiperidine
- Synonyms
- tert-butyl (S)-3-hydroxypiperidine-1-carboxylate;(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Ibrutinib Interm 0441;1,1-DiMethylethy;(S)-BOC-piperidinol;Ilutinib impurity 7;(S)-1-BOC-3-PIPERIDINOL;（S）-N-BOC-3-piperidinol;(S)-1-BOC-Piperidin-3-ol;(S)-1-Boc-3-hydroxypiperi...
- CBNumber:
- CB6197360
- Molecular Formula:
- C10H19NO3
- Molecular Weight:
- 201.26
- MOL File:
- 143900-44-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 34-40 °C |
|---|---|
| Boiling point | 292.3±33.0 °C(Predicted) |
| Density | 1.107±0.06 g/cm3(Predicted) |
| Flash point | 110 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in methanol. |
| pka | 14.74±0.20(Predicted) |
| form | Powder or Crystalline Powder |
| color | White to tan |
| optical activity | [α]22/D +10.0°, c = 1 in chloroform |
| InChI | InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1 |
| InChIKey | UIJXHKXIOCDSEB-QMMMGPOBSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1 |
| CAS DataBase Reference | 143900-44-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
(S)-1-Boc-3-hydroxypiperidine price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 687367 | (S)-1-Boc-3-hydroxypiperidine 97% | 143900-44-1 | 1G | ₹6570.78 | 2022-06-14 | Buy |
| ALFA India | ALF-H52771-06 | (S)-1-Boc-3-hydroxypiperidine, 97% | 143900-44-1 | 5g | ₹7799 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B4446 | (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine min. 98.0 % | 143900-44-1 | 1G | ₹2600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B4446 | (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine min. 98.0 % | 143900-44-1 | 5G | ₹8800 | 2022-05-26 | Buy |
| ALFA India | ALF-H52771-03 | (S)-1-Boc-3-hydroxypiperidine, 97% | 143900-44-1 | 1g | ₹7459 | 2022-05-26 | Buy |
(S)-1-Boc-3-hydroxypiperidine Chemical Properties,Uses,Production
Description
(S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.
Chemical Properties
White powder
Uses
A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.
(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 617)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aastrid Life Sciences Private Limited | +91-91-22-40072626 +91-7304494278 | Mumbai, India | 95 | 58 | Inquiry |
| Bulat Pharmaceutical Pvt Ltd | +91-8448085659 +91-8448085660 | Haryana, India | 123 | 58 | Inquiry |
| Suven Pharmaceuticals Limited | +91-91-40-23541142 +91-4023541142 | Telangana, India | 218 | 58 | Inquiry |
| Vidgas science and technologies Pvt Ltd | +91-9030019844 +91-9030019844 | Telangana, India | 76 | 58 | Inquiry |
| Vibrant Life Sciences | +917989177519 | Telangana, India | 25 | 58 | Inquiry |
| Aarti Industries Limited (AIL) | +91-84596144931 +91-9920899935 | Maharashtra, India | 235 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
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