Mavacamten
- CAS No.
- 1642288-47-8
- Chemical Name:
- Mavacamten
- Synonyms
- YMK-461;MYK-461 (SAR-439152);MYK-461;SAR439152;Mawakatan;SAR-439152;SAR 439152;Mavacamten;Mavacampten;Mava Kaitai
- CBNumber:
- CB23170382
- Molecular Formula:
- C15H19N3O2
- Molecular Weight:
- 273.33
- MOL File:
- 1642288-47-8.mol
- Modify Date:
- 2024/9/12 21:58:09
| Density | 1.19±0.1 g/cm3(Predicted) |
|---|---|
| solubility | insoluble in H2O; ≥11.32 mg/mL in EtOH with ultrasonic; ≥13.65 mg/mL in DMSO |
| form | solid |
| pka | 8.83±0.40(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1 |
| InChIKey | RLCLASQCAPXVLM-NSHDSACASA-N |
| SMILES | C1(=O)NC(N[C@H](C2=CC=CC=C2)C)=CC(=O)N1C(C)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H410-H372 |
| Precautionary statements | P264-P270-P273-P301+P312-P330-P391-P501 |
Mavacamten Chemical Properties,Uses,Production
Description
Mavacamten（MYK-461）is a first-in-class allosteric inhibitor of cardiac myosin that promises to provide clinicians with targeted therapy for these patients. It is a mechanistically novel small molecule that acts on the sarcolemma to specifically inhibit contractility and has been proposed as a treatment for HCM.
Uses
MYK-461 is a drug used to treat obstructive hypertrophic cardiomyopathy as a cardiac myosin inhibitor. Mavacamten is used to treat adults with symptomatic obstructive hypertrophic cardiomyopathy. It is used to treat symptomatic obstructive hypertrophic cardiomyopathy (HCM).
Mechanism of action
Mavacamten is thought to work by reducing cardiac muscle contractility by inhibiting excessive myosin-actin cross-bridge formation that results in hypercontractility, left ventricular hypertrophy and reduced compliance. In clinical and preclinical studies, it has consistently reduced biomarkers of cardiac wall stress, lessened excessive cardiac contractility, and increased diastolic compliance.
Side effects
Common side effects include:Dizziness, fainting, Incidence not known, Chest pain or tightness, decreased urine output, dilated neck veins, irregular breathing, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, unusual tiredness or weakness and weight gain.
Mavacamten Preparation Products And Raw materials
Raw materials
Preparation Products
Mavacamten Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| VCS Chem Tech Pvt Ltd | +91-8008851342 +91-8008851342 | Telangana, India | 66 | 58 | Inquiry |
| Apicore Pharmaceuticals Pvt Ltd | +91-2662267177 +91-2662267166 | Gujarat, India | 181 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd | +86-02223869539 +86-15560057295 | China | 27 | 58 | Inquiry |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | China | 297 | 58 | Inquiry |
| Jinan Jianfeng Chemical Co., Ltd | +8615562555968 | China | 247 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12495 | 58 | Inquiry |
| HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 | China | 304 | 58 | Inquiry |
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | China | 294 | 58 | Inquiry |