ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
- CAS No.
- 397864-40-3
- Chemical Name:
- 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
- Synonyms
- GW675713X;BNKY012-FF04;Fluticasone furoate impurity 03;Fluticasone Carbothioic Acid Fuorate;6α,9-Difluoro-11-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17-yl-2-furancarboxylate carbothioic S-acid;6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid;6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid;6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-（1-1-furancarboxylic）-1,4-diene-17β-thiocarboxylic acid;Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxo-, (6α,11β,16α,17α)-;(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid (>85%)
- CBNumber:
- CB23372041
- Molecular Formula:
- C26H28F2O6S
- Molecular Weight:
- 506.56
- MOL File:
- 397864-40-3.mol
- Modify Date:
- 2024/3/15 11:45:59
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid Properties
| Melting point | >154°C (dec.) |
|---|---|
| Boiling point | 622.1±55.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chlroform (Slightly, Heated, Sonicated) |
| form | Solid |
| pka | 2.97±0.70(Predicted) |
| color | White to Off-White |
| Stability | Air Sensitive |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H373-H410-H360 |
| Precautionary statements | P260-P314-P501-P273-P391-P501 |
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid Chemical Properties,Uses,Production
Uses
(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid is a steroid used in the preparation of crystalline forms of the therapeutically useful anti-inflammatory corticosteroid fluticasone furoate (I) and its solvates. A fluticasone furoate (F599510) impurity.
Synthesis
A suspension of 17β-[(N, N-dimethylcarbamoyl)thio]carbonyl-6α,9α-difluoro-17α-[(2-furanylcarbonyl)oxy]-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene (14.2 g, 0.024 mol) and potassium carbonate (6.78 g, 0.0491 mol) in methanol (70 ml) was stirred at ambient temperature for 6 hrs under a blanket of nitrogen. After that, water was added to the reaction mixture, and the clear solution was washed with toluene. The aqueous layer containing the product was charcoalized and then acidified with 2N HCl until pH was 1.5 to 2.0. The precipitated product was filtered, washed with water, and dried to yield 6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid as a white solid (11.8 g, 94.8%).
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid Preparation Products And Raw materials
Raw materials
Preparation Products
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid Suppliers
Global( 27)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| BIONNA MEDICINE CO.,LTD | 01056380788-8515; +8618518759099 | China | 52 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10991 | 58 | Inquiry |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | China | 11927 | 58 | Inquiry |
| Shanghai Zerui Biotechnology Co., Ltd. | 021-54580889 18321124657 | China | 10614 | 58 | Inquiry |
| TOSUN PHARM | 020-61855200 13326451905 | China | 7723 | 58 | Inquiry |
| Shandong Mopai Biotechnology Co., Ltd | 13070690626 13053322091 | China | 11056 | 58 | Inquiry |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 | China | 9911 | 50 | Inquiry |
| Shenzhen Qingtian Biotechnology Co, Ltd. | 18823167005 18162969855 | China | 2628 | 58 | Inquiry |
397864-40-3(6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid)Related Search:
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
BNKY012-FF04
GW675713X
Fluticasone Carbothioic Acid Fuorate
Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxo-, (6α,11β,16α,17α)-
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-((furan-2-carbonyl)oxy)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioic S-acid
(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid (>85%)
6α,9α-difluoro-17α-(furan-2-yl)carbonyloxy-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioic acid
Fluticasone Thioacid-17-furoateQ: What is
Fluticasone Thioacid-17-furoate Q: What is the CAS Number of
Fluticasone Thioacid-17-furoate
6α,9-Difluoro-11-hydroxy-16α-methyl-3-oxo-androsta-1,4-diene-17-yl-2-furancarboxylate carbothioic S-acid
Fluticasone furoate impurity 03
6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-（1-1-furancarboxylic）-1,4-diene-17β-thiocarboxylic acid
Fluticasone Impurity(6α,9α-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-17α-（1-1-furancarboxylic）-1,4-diene-17β-thiocarboxylic acid)
397864-40-3
C26H28F2O6S