RESCINNAMINE
- CAS No.
- 24815-24-5
- Chemical Name:
- RESCINNAMINE
- Synonyms
- Rozex;Apolon;Rescin;Tuareg;ANAPREL;Anapral;Cartric;Moderil;Resipal;Apoterin
- CBNumber:
- CB2344278
- Molecular Formula:
- C35H42N2O9
- Molecular Weight:
- 634.73
- MOL File:
- 24815-24-5.mol
- Modify Date:
- 2023/5/4 17:34:36
| Melting point | 238-239°C |
|---|---|
| alpha | D24 -97° (c = 1 in chloroform) |
| Boiling point | 669.26°C (rough estimate) |
| Density | 1.2161 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | pKa 6.4 (Uncertain) |
| color | Pale Beige to Pale Brown |
| Stability | Stable, but darkens slowly in light. Incompatible with strong oxidizing agents. |
| EPA Substance Registry System | Rescinnamine (24815-24-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H332-H312 |
| Precautionary statements | P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312 |
| Hazard Codes | Xn |
| Risk Statements | 25-20/21/22 |
| Safety Statements | 22-45-36 |
| RIDADR | 1544 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
RESCINNAMINE Chemical Properties,Uses,Production
Description
This Rauwolfia alkaloid is found in the barks of R. serpentina and R. vomitora and was originally given the name Reserpinine, this being altered to avoid confusion with another alkaloid of the same name (q.v.). The base has [α]17D - 99.2° (c 1.3, CHCI3). From chemical degradation and spectroscopic analysis, the structure has been established as the 3:4: 5-trimethoxycinnamoyl ester of reserpic acid.
Chemical Properties
white to cream powder
Uses
Rescinnamine occurs in the roots of a num ber of Rauwolfia species. Therapeutically, itis used as an antihypertensive agent.
General Description
Odorless white to cream colored crystalline powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
The neat material darkens slowly on exposure to light. In solution this occurs more rapidly. .
Health Hazard
The pharmacological properties of rescinnamine are similar to those of reserpine, butthe side effects are low. It acts as a sedativeand hypotensive. A dose of 0.25 mg/day mayproduce the effect of sleepiness in humans.Excessive doses may produce depression,nightmare, nausea, diarrhea, and hypotension.
LD50 value, oral (rats): 1000 mg/kg
The carcinogenicity of rescinnamine inanimals or humans is unknown.
Fire Hazard
Flash point data for RESCINNAMINE are not available. RESCINNAMINE is probably combustible.
Purification Methods
Crystallise it from *benzene, MeOH or aqueous Me2CO. The hydrochloride has m 232o(dec) (from MeOH) and [] D -74o (MeOH). It is an antihypertensive. [Klohs et al. J Am Chem Soc 77 2241 1955, Beilstein 25 III/IV 1323.]
References
Haack e tal., Naturwiss., 41, 214 (1954)
Klohs, Draper, Keller.,J. Amer. Chem. Soc., 77,2241 (1955)
Kidd., Chem. & Ind., 1481 (1955)
Popelak, Lettenbauer., Arch. Pharm., 296,261 (1963)
RESCINNAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10991 | 58 | Inquiry |
| ABCR GmbH & CO. KG | 49 721 95061 0 | Germany | 6846 | 75 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 8672 | 58 | Inquiry |
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-87576359 15353716720 | China | 10011 | 58 | Inquiry |
| Scandinavian Formulas | 800-688-2276 | United States | 1550 | 58 | Inquiry |
| United States Biological | 800.520.3011 or 781.639.5092 | United States | 6256 | 80 | Inquiry |
| Beijing PUXI Technology Co., Ltd | 400-8087372 13161114455 | China | 4990 | 58 | Inquiry |
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