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Vinflunine

Vinflunine Structure
CAS No.
162652-95-1
Chemical Name:
Vinflunine
Synonyms
VINFLUNINE;vinflunine（97%）;Vinflunine Tartrate;Vinflunine (F12158);Vinflunine USP/EP/BP;Vinflunine 162652-95-1;20',20'-Difluoro-3',4'-dihydrovinorelbine;4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine;4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine;Aspidospermidine-3-carboxylicacid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-1
CBNumber:
CB2358406
Molecular Formula:
C45H54F2N4O8
Molecular Weight:
816.94
MOL File:
162652-95-1.mol
Modify Date:
2022/12/21 16:56:50
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Vinflunine Properties

Density 1.39±0.1 g/cm3(Predicted)
pka 11.36±0.60(Predicted)
CAS DataBase Reference 162652-95-1(CAS DataBase Reference)

Vinflunine Chemical Properties,Uses,Production

Description

Vinflunine (also referred to as PM391) is a semisynthetic analog of the natural vinca alkaloids vinblastine and vincristine that was approved by the European Medicines Agency (EMEA) in 2009 for the treatment of adult patients with advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a prior platinum-containing regimen. Vinflunine is synthesized from anhydrovinblastine in a superacid media (HF-SbF5) and in the presence of a chlorinated solvent like CHCl3 or CCl4.

Definition

ChEBI: An organic heteropentacyclic compound and an organic heterotetracyclic compound that is vinorelbine in which the tetrahydropyridine moiety of the heterotetracyclic part of the molecule has been redced to the corresponding piperidine, and in which the ethy group attached to this ring has been replaced by a 1,1-difluoroethyl group.

Vinflunine Preparation Products And Raw materials

Raw materials

Vinorelbine

Preparation Products

Vinflunine Suppliers

Global( 100)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Manus Aktteva +91 (79) 6512-3395 New Delhi, India 581 34 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21677 55 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23556 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26368 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
changzhou huayang technology co., ltd +8615250961469 China 9821 58 Inquiry
Supplier Advantage
Manus Aktteva 34
Henan Tianfu Chemical Co.,Ltd. 55
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
SIMAGCHEM CORP 58
ANHUI WITOP BIOTECH CO., LTD 58
Dideu Industries Group Limited 58
AFINE CHEMICALS LIMITED 58
Zhejiang J&C Biological Technology Co.,Limited 58
changzhou huayang technology co., ltd 58

162652-95-1(Vinflunine)Related Search:

(R)-3-AMINO-4-(3-METHYLPHENYL)BUTANOIC ACID HYDROCHLORIDE 2,4-Dipentylphenol 3-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID 2-TERT-BUTYL-1H-INDOLE 4-PHENYLCYCLOHEXANOL
α-(p-Aminophenyl)butyric acid (2S)-2,3-Dihydroxy-2-methyl-propanoic Acid Methyl Ester 90% TRANS-4-AMINOCYCLOHEXANECARBOXYLIC ACID 4-AMINOCYCLOHEXANECARBOXYLIC ACID (R)-(-)-2-HYDROXY-4-PHENYLBUTYRIC ACID
Vinflunine INDOLE-2-ACETIC ACID 3,3,5,5-TETRAMETHYLCYCLOHEXANOL 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID L-LEUCIC ACID
(2-METHOXY-5-METHYLPHENYL)ACETIC ACID 3-PHENETHYL-PIPERIDINE (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID HYDROCHLORIDE
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VINFLUNINE 20',20'-Difluoro-3',4'-dihydrovinorelbine 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine 4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine Vinflunine Tartrate Vinflunine 162652-95-1 Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)- Vinflunine USP/EP/BP Vinflunine (F12158) Aspidospermidine-3-carboxylicacid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-1 vinflunine（97%） Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)- 162652-95-1 C45H54F2N4O8 Miscellaneous Natural Products