Triptorelin
- CAS No.
- 57773-63-4
- Chemical Name:
- Triptorelin
- Synonyms
- TRIPTORELIN PAMOATE;Triptorelin/GnRH;PGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2;CL-118532;TRIPORELIN;Decapeptyl;Triptoreli;TRIPTORELIN;Tryptorelin;Triprerelin
- CBNumber:
- CB2366465
- Molecular Formula:
- C64H82N18O13
- Molecular Weight:
- 1311.45
- MOL File:
- 57773-63-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/7 19:09:42
| Melting point | >180°C (dec.) |
|---|---|
| alpha | D23 -58.8° (c = 0.33 in acetic acid) |
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Aqueous Base (Slightly), Methanol (Very Slightly, Heated, Sonicated) |
| form | powder |
| pka | 9.82±0.15(Predicted) |
| color | White to Off-White |
| Stability | Hygroscopic |
| InChIKey | HPPONSCISKROOD-OYLNGHKZSA-N |
| CAS DataBase Reference | 57773-63-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360 |
| Precautionary statements | P201-P308+P313 |
| Hazard Codes | T |
| Risk Statements | 60 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| HS Code | 2937190000 |
Triptorelin price More Price(2)
Triptorelin Chemical Properties,Uses,Production
Description
Decapeptyl is a modified (D-Trp6) LH-RH. Like recently marketed buserelin and leuprolide (I), it is useful in achieving medical castration in the treatment of advanced prostate cancer.
Uses
Triptorelin is a GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferation.
Definition
ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-tryptophyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It is an agonist analogue of gonadotropin-releasing hormone.
Clinical Use
Triptorelin pamoate is another superagonist of GnRH, which like nafarelin acetate contains only a single amino acid substitution (D-Trp6 for Gly6) when compared to the natural hormone. In the treatment of advanced prostate cancer, it is important to reduce serum testosterone levels to very low levels, which can be achieved surgically by orchiectomy. When this surgical method is unacceptable to the patient, an alternative approach is “chemical castration,” which can be achieved by use of estrogen therapy, leuprolide,goserelin or histrelin acetates, and now, triptorelin pamoate. This product is available for IM depot injection (monthly or every 3 months), wherein serum testosterone concentration drops to a level generally seen in surgically castrated men.
Side effects
The side effects of Triptorelin: Painful or difficult urination, burning when you urinate, blood in the urine; bone pain; (in children) new or worsening signs of puberty; a seizure; chest pain or pressure, pain spreading to your jaw or shoulder; sudden numbness or weakness, slurred speech; increased pressure inside the skull - severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; loss of movement in any part of your body; high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor; or nerve problems - back pain, muscle weakness, problems with balance or coordination, severe numbness or tingling in your legs or feet, loss of bladder or bowel control.
Mode of action
Triptorelin is a gonadotrophin releasing hormone (GnRH) blocker. This means it stops messages from a part of the brain called the hypothalamus that tells the pituitary gland Open a glossary item to produce luteinising hormone. Luteinising hormone tells the testicles to produce testosterone Open a glossary item. So, blocking GnRH stops the testicles producing testosterone. Prostate cancer depends on testosterone to grow. So triptorelin can shrink the cancer or slow its growth. In women, it stops the ovaries Open a glossary item from producing oestrogen. Some breast cancers depend on oestrogen to grow. Lowering the level of oestrogen can slow or stop the growth of the cancer.
Triptorelin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Apicore Pharmaceuticals Pvt Ltd | +91-2662267177 +91-2662267166 | Gujarat, India | 181 | 58 | Inquiry |
| srinivas | 09948052729 | Hyderabad, India | 1 | 58 | Inquiry |
| Hemmo Pharmaceuticals Private Limited | 08048361298Ext 414 | Mumbai, India | 6 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | China | 616 | 58 | Inquiry |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | China | 999 | 58 | Inquiry |
Related articles
- Triptorelin: uses and Pharmacokinetics
- Triptorelin is administered to patients in the form of acetate or pamoate (also known as embonate) salts.
- Jun 19，2024
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