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PAXILLINE

CAS No.: 57186-25-1

Chemical Name:: PAXILLINE

Synonyms: PAXILINE;mycillin;PAXILLINE;Paxicillin;Paxilline solution;PAXILLINE, PENICILLIUM PAXILLI;paxilline from penicillium paxilli;4b-beta,6a-alpha,12b-beta,12c-alpha,14a-beta)-2-alph;14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-(;2h-1-benzopyrano(5’,6’:6,7)indeno(1,2-b)indol-3(4bh)-one,5,6,6a,7,12,12b,12c,1

CBNumber:: CB2402640

Molecular Formula:: C27H33NO4

Molecular Weight:: 435.56

MOL File:: 57186-25-1.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

PAXILLINE Properties

Flash point	2℃
storage temp.	2-8°C
solubility	Soluble in DMSO, acetone or chloroform.
form	powder
color	faint yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS06

Signal word

Danger

Hazard statements

H301+H311+H331-H315-H318-H335

Precautionary statements

P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338

Hazard Codes

T,Xn,F

Risk Statements

23/24/25-36/37/38-41-36-20/21/22-11

Safety Statements

26-36/37/39-45-36/37-16

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

DJ2830000

HazardClass

6.1(b)

PackingGroup

III

HS Code

29419090

NFPA 704

	0
4		0

PAXILLINE price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	P2928	Paxilline powder, ≥98% (HPLC)	57186-25-1	5MG	₹38385.45	2022-06-14	Buy
Sigma-Aldrich(India)	P2928	Paxilline powder, ≥98% (HPLC)	57186-25-1	10MG	₹68489.78	2022-06-14	Buy

Product number	Packaging	Price	Buy
P2928	5MG	₹38385.45	Buy
P2928	10MG	₹68489.78	Buy

PAXILLINE Chemical Properties,Uses,Production

Description

A complex alkaloid, paxilline occurs in the mycelium of the mold Penicillium paxilli. The structure has been confirmed by X-ray crystallography. The crystals are orthorhombic with space group P2 12 121 and a = 31.009, b = 11.522 and c = 7.70 A.

Chemical Properties

Powder

Uses

Paxilline is a tremorgenic mycotoxin isolated from species of Penicillium, Acremonium and Emericella. Paxilline selectively blocks high-conductance Ca2+-activated potassium channels and inhibits binding to the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor.

Biological Activity

Potent blocker of high-conductance Ca 2+ -activated K + (BK Ca ) channels. Binds to the α -subunit of BK Ca (K i = 1.9 nM for block of currents in α -subunit-expressing oocytes) and enhances binding of charybdotoxin to BK Ca channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca 2+ -ATPase (IC 50 = 5-50 μ M).

Enzyme inhibitor

This BKCa/KCa1.1) channel blocker (FW = 435.56 g/mol; CAS 57186-25-1; Solubility: 100 mM in DMSO), also named (2R,4bS,6aS,12bS,12cR,14aS)- 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1- methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'': 5',6']benz[1',2':6,7]indeno [1,2-b]indol-3(4bH)-one, binds to the α-subunit of BKCa, exhibiting a Ki value of 1.9 nM in blocking currents in α-subunit-expressing oocytes and enhancing binding of to BKCa channels in vascular smooth muscle. (See Charybdotoxin) Paxilline also inhibits sarco/endoplasmic reticulum Ca2+-ATPase, IC50 = 5 - 50 μM.

References

Springer et ai., Tetrahedron Lett., 2531 (1975)

PAXILLINE Preparation Products And Raw materials

Raw materials

Preparation Products

PAXILLINE Suppliers

Global( 112)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-19164747840 +86-13119157289	China	2971	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
RD International Technology Co., Limited	18024082417	China	9274	58	Inquiry
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	China	4664	58	Inquiry
Shanghai klamar Reagent Co., LTD	4001650900 13817534909	China	10709	58	Inquiry
Wuhan Dingxintong Pharmaceutical Co. , Ltd.	027-027-52344656 15871722230	China	4215	58	Inquiry
Lingyuan Bebiansen Biological Technology Co., Ltd	18642120371	China	7994	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
TargetMol Chemicals Inc.	58
BOC Sciences	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Aladdin Scientific	58
RD International Technology Co., Limited	58
Dalian Meilun Biotech Co., Ltd.	58
Shanghai klamar Reagent Co., LTD	58
Wuhan Dingxintong Pharmaceutical Co. , Ltd.	58
Lingyuan Bebiansen Biological Technology Co., Ltd	58

57186-25-1(PAXILLINE)Related Search:

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(2R)-5,6,6aα,7,12,12b,12c,13,14,14aβ-Decahydro-4bβ-hydroxy-2-(1-hydroxy-1-methylethyl)-12bβ,12cα-dimethyl-2H-1-benzopyrano[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one 2h-1-benzopyrano(5’,6’:6,7)indeno(1,2-b)indol-3(4bh)-one,5,6,6a,7,12,12b,12c,1 4b-beta,6a-alpha,12b-beta,12c-alpha,14a-beta)-2-alph paxilline from penicillium paxilli PAXILINE Paxicillin (2R,4bS,6aS,12bS,12cR,14aS)-4b-Hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5′,6′:6,7]indeno[1,2-b]indol-3(4bH)-one solution Paxilline solution PAXILLINE PAXILLINE, PENICILLIUM PAXILLI (2R,4BS,6AS,12BS,12CR,14AS)-5,6,6A,7,12,12B,12C,13,14,14A-DECAHYDRO-4B-HYDROXY-2-(1-HYDROXY-1-METHYLETHYL)-12B,12C-DIMETHYL-2H-PYRANO[2'',3'':5',6']BENZ[1',2':6,7]INDENO[1,2-B]INDOL-3(4BH)-ONE 14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-( 2H-1-Benzopyrano[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2R,4bS,6aS,12bS,12cR,14aS)- Paxilline,(2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one 4b-Hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one mycillin 57186-25-1 C27H33NO4 BioChemical Cell Biology Cell Signaling and Neuroscience Monovalent Ion Channels Potassium Channel Modulators Ion Channels Voltage-gated Ion Channels MoldVoltage-gated Ion Channels Cell Signaling and Neuroscience Monovalent Ion Channels Potassium Channel Modulators Toxins and Venoms Potassium channel antibiotic