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(-)-BETA-HYDRASTINE

(-)-BETA-HYDRASTINE Structure
CAS No.
118-08-1
Chemical Name:
(-)-BETA-HYDRASTINE
Synonyms
HYDRASTINE;l-hydrastine;Hydrastine-RM;Hydrastinebase;(-)-Hydrastine;quinolin-5-yl)-;(+/-)-Nor-β(-)--Hydrastine;(-)-B-HYDIASTINE;9S)-β-Hydrastine
CBNumber:
CB2456153
Molecular Formula:
C21H21NO6
Molecular Weight:
383.39
MOL File:
118-08-1.mol
Modify Date:
2024/11/19 23:02:33
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(-)-BETA-HYDRASTINE Properties

Melting point 132℃
alpha D20 -50° (c = 0.3 in abs alc)
Boiling point 510.32°C (rough estimate)
Density 1.339±0.06 g/cm3 (20 ºC 760 Torr)
refractive index 1.5614 (estimate)
storage temp. −20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml
form A crystalline solid
pka 7.8(at 25℃)
color White to light yellow
Water Solubility 30mg/L(20 ºC)
CAS DataBase Reference 118-08-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
RIDADR  1544
WGK Germany  3
RTECS  MU6030000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2939800000
NFPA 704
0
3 0

(-)-BETA-HYDRASTINE Chemical Properties,Uses,Production

Description

(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.

Definition

ChEBI: A natural product found in Hydrastis canadensis.

(-)-BETA-HYDRASTINE Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-BETA-HYDRASTINE Suppliers

Global( 89)Suppliers
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
Chengdu Biopurify Phytochemicals Ltd. +86-28-82633860; +8618080483897 China 3772 58 Inquiry
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Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49734 58 Inquiry
TargetMol Chemicals Inc. United States 38630 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43340 58 Inquiry
Mensura Group Limited +8618109034517 China 2900 58 Inquiry
58896805 CHINA 15620 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Chengdu Biopurify Phytochemicals Ltd. 58
Career Henan Chemica Co 58
Shaanxi Didu New Materials Co. Ltd 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
TargetMol Chemicals Inc. 58
LEAPCHEM CO., LTD. 58
Mensura Group Limited 58
58

(-)-BETA-HYDRASTINE Spectrum

(-)-BETA-HYDRASTINE(118-08-1)IR1(-)-BETA-HYDRASTINE(118-08-1)IR2

118-08-1((-)-BETA-HYDRASTINE)Related Search:

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NOSCAPINE HYDROCHLORIDE (+)-BETA-HYDRASTINE HCL HYDRASTININE HCL(RG) (+)-BETA-HYDRASTINE,D-BETA-HYDRASTINE,(1S,9R)-BETA-HYDRASTINE HYDRASTININE HYDROCHLORIDE
NOSCAPINE HYDROCHLORIDE HYDRATE AKOS 244-30 TIMTEC-BB SBB006457
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HYDRASTINE, (-)-B-(P) (AHP Verified) HYDRASTINE, (-)-B-(P) Hydrastine (base and/or unspecified salts) (1R,9S)-(-)-β-Hydrastine (3R)-6,7-Dimethoxy-3-[[(1R)-1,2,3,4-tetrahydro-2-methyl-6,7-(methylenedioxy)isoquinoline]-1-yl]isobenzofuran-1(3H)-one [R,(-)]-6,7-Dimethoxy-3-[[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinoline]-5-yl]isobenzofuran-1(3H)-one (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone [S,(-)]-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]isobenzofuran-1(3H)-one 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one 6,7-dimethoxy-3-(6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one (1R,9S)-B-hydrastine free base Hydrastinebase Hydrastine (10 mg) l-beta-Hydrastine l-hydrastine Phthalide, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)- phthalide,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)iso quinolin-5-yl)- HYDRASTINE HYDRASTINE, (-)-B- (-)-BETA-HYDRASTINE (-)-B-HYDIASTINE (1R,9S)-(-)-BETA-HYDRASTINE (1R,9S)-BETA-HYDRASTINE [S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-isobenzofuranone 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]- 6,7-Dimethoxy-3-(6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one HYDRASTINE (D-beta-) (-)-Β-HYDRASTINE;(1R;9S)-Β-HYDRASTINE 9S)-β-Hydrastine N-Desmethyl &beta (+/-)-Nor-&beta 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)- (1R,9S)-(–)-β-Hydrastine (-)-β-Hydrastine (-)--Hydrastine Hydrastine (1313210) (-)-Hydrastine (S)-6,7-dimethoxy-3-((R)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one Hydrastine,Inhibitor,inhibit Hydrastine-RM Hydrastine, 10 mM in DMSO 118-08-1 XYLOCAINE Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals