STAUROSPORINE | 62996-74-1

STAUROSPORINE Properties

Melting point	270°C
alpha	D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)
Boiling point	677.5±55.0 °C(Predicted)
Density	1.56±0.1 g/cm3(Predicted)
RTECS	KD5084000
storage temp.	2-8°C
solubility	DMSO: soluble
form	White to pale yellow solid
pka	14.25±0.70(Predicted)
color	Off white to pale yellow
Water Solubility	Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.
BRN	1060573
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey	HKSZLNNOFSGOKW-WIFUGMKFSA-N
CAS DataBase Reference	62996-74-1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08

Signal word

Warning

Hazard statements

H361d-H413

Precautionary statements

P201-P202-P273-P280-P308+P313-P405

Hazard Codes

Xn,T,Xi

Risk Statements

40-45-36/37/38-46

Safety Statements

36/37-53-36-26-45

RIDADR

UN 2811 6.1 / PGII

WGK Germany

2

F

8-10

HazardClass

3

HS Code

29419090

NFPA 704

	0
4		0

STAUROSPORINE price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	S5921	Staurosporine from Streptomyces sp. for molecular biology, ≥95% (HPLC)	62996-74-1	0.1MG	₹24540.28	2022-06-14	Buy
Sigma-Aldrich(India)	S5921	Staurosporine from Streptomyces sp. for molecular biology, ≥95% (HPLC)	62996-74-1	0.5MG	₹82118.45	2022-06-14	Buy
Sigma-Aldrich	S5921	Staurosporine from Streptomyces sp. for molecular biology, ≥95% (HPLC)	62996-74-1	1MG	₹146256.58	2022-06-14	Buy
Sigma-Aldrich(India)	S5921	Staurosporine from Streptomyces sp. for molecular biology, ≥95% (HPLC)	62996-74-1	1MG	₹146256.58	2022-06-14	Buy
Sigma-Aldrich(India)	S4400	Staurosporine from Streptomyces sp. ≥98% (HPLC), film	62996-74-1	0.1MG	₹23262.93	2022-06-14	Buy

Product number	Packaging	Price	Buy
S5921	0.1MG	₹24540.28	Buy
S5921	0.5MG	₹82118.45	Buy
S5921	1MG	₹146256.58	Buy
S5921	1MG	₹146256.58	Buy
S4400	0.1MG	₹23262.93	Buy

STAUROSPORINE Chemical Properties,Uses,Production

Description

Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC₅₀ value of 2.7 nM. It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively. However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms. The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.

Chemical Properties

Light Yellow Solid

Occurrence

A complex alkaloid. staurosporine has been isolated from a strain of Streptomyces.

Uses

Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumour active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.

General Description

A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC₅₀ = 20 nM), myosin light chain kinase (IC₅₀ = 1.3 nM), protein kinase A (IC₅₀ = 7 nM), protein kinase C (IC₅₀ = 0.7 nM), and protein kinase G (IC₅₀ = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G₁ checkpoint.

Biological Activity

Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

STAUROSPORINE Preparation Products And Raw materials

Raw materials

9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2-[(3,4-dimethoxyphenyl)methyl]-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]- (9CI) 9,13-Epoxy-1H,11H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonine-1,11-dione, 2-[(3,4-dimethoxyphenyl)methyl]-2,3,9,10,12,13-hexahydro-10-methoxy-9-methyl-, 11-(O-methyloxime), [9S-(9α,10β,11Z,13α)]- (9CI)

Preparation Products

STAUROSPORINE Suppliers

Global( 361)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Clearsynth Labs	91-22-45045900	Maharashtra, India	3889	58	Inquiry
ENBRIDGE PHARMTECH CO., LTD.	+8613812269233	China	303	58	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	China	12452	58	Inquiry
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	China	986	58	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20296	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
SynZeal Research Pvt Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Pharma Affiliates	58
Clearsynth Labs	58
ENBRIDGE PHARMTECH CO., LTD.	58
Hebei Mojin Biotechnology Co., Ltd	58
Hangzhou ICH Biofarm Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58

STAUROSPORINE Spectrum

STAUROSPORINE(62996-74-1)¹HNMR

62996-74-1(STAUROSPORINE)Related Search:

Succinylcholine Chloride Methimazole Diphenhydramine Hydrochloride Staurosporine, Streptomyces sp. STAUROSPORINE AGLYCONE

1,2,3,4-Tetrahydro Staurosporine STAUROSPORINE,STAUROSPORINE, STREPTOMYCES SPECIES,STAUROSPORINE, STREPTOMYCES STAUROSPOREUS ent-Staurosporine INSTA-Blot, Apoptotic HeLa Cells, Staurosporine-Treated INSTA-BLOT(TM), APOPTOTIC HL-60 CELLS, STAUROSPORINE-TREATED

{ STAUROSPORINE--N/H Staurosporine, Streptomyces sp. in Solution INSTA-BLOT(TM), APOPTOTIC HELA CELLS, STAUROSPORINE-TREATED INSTA-BLOT(TM), APOPTOTIC JURKAT CELLS, STAUROSPORINE-TREATED INSTA-Blot, Apoptotic Jurkat Cells, Staurosporine-Treated

JURKAT AND STAUROSPORINE LYSATE (8H),JURKAT AND STAUROSPORINE LYSATE (4H) STAUROSPORINE READY MADE INSTA-Blot, Apoptotic HL-60 Cells, Staurosporine-Treated

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9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]- InSolution Staurosporine, Streptomyces sp Staurosporineinsolution 9,13-Epoxy-1H,9H-diindolo1,2,3-gh:3,2,1-lmpyrrolo3,4-j1,7benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)- Staurosporine, Antibiotic AM-2282 (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one Antibiotic 230 CGP 39360 [9S-(9alpha,10beta,11beta,13alpha)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-1m]pyrrolo[3,4-j][1,7]benzodiazonin-1-one (9S,10α,11α,13β)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one STAUROSPORINE, STREPTOMYCES SPECIES STAUROSPORINE, STREPTOMYCES STAUROSPOREUS [9S,10α,11α,13β,(+)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one Staurosporine,98% [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one Staurosporine,AM-2282,STS yT5720idec Monophosphorothioate, Rp-IsoMer, TriethylaMMoniuM SaltuM Saltnoic acid salt Staurosporine(CGP 41251) ANTIBIOTIC M 193 ANTIBIOTIC AM-2282 [9S-(9A,10B,11B,13A)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-1M]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE 2,3,10,11,12,13-HEXAHYDRO-10R-METHOXY-9S-METHYL-11R-METHYLAMINO-9S,13R-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1 ONE STAUROSPORINE FROM STREPTOMYCES SP. STAUROSPORINE READY-MADE SOLUTION STAUROSPORINE, 99+%. STAUROSPORINE FROM STREPTOMYCES SP MOLECULAR BIOLOGY REAGENT 98+% AM 2282, M 193 STAUROSPORINE FROM STREPTOMYCES SP., PGE WITH 250 UG STAUROSPORINE Staurosporine, 98%, from Streptomyces sp. Staurosporine, 98%, reagent grade STAUROSPORINE USP/EP/BP Staurosporine (AM-2282) US-DMF No.: 034763 CS-2206 CBR113 AM-2282 Staurosporin Stauroporine STSP Star spore fungus (5S,6R,7R,9R)-6-Methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one Sporosin Staurosporine (PKC inhibitors) (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14(5H)-one Astrosporin CCRIS 3272 62996-74-1 C28H26N4O3 BioChemical Antibiotics N-S Antibiotics A to Z Antibiotics Inhibitor All Inhibitors Signalling Inhibitors Intermediates & Fine Chemicals